Lee E H, Tsai M J
Institute of Biomedical Sciences, Academia Sinica Taipei, Taiwan, Republic of China.
Behav Neural Biol. 1989 May;51(3):412-23. doi: 10.1016/s0163-1047(89)91052-2.
We have previously demonstrated that both stress manipulations and corticotropin-releasing factor (CRF) elevate locomotor activity in mice primarily in the center region of an open field. In the present study, other than confirming these findings, we have further examined the roles of the dentate gyrus of the hippocampus, the amygdala, and the caudate nucleus in mediating the locomotor-stimulating effect of CRF. Results indicate that among the areas examined, the hippocampus is the most important neural substrate of the action of CRF. The amygdala is also partly responsible for the behavioral effect produced by CRF. The caudate nucleus, however, although is important in the expression of gross motor activity, is not involved in the effect of CRF on locomotion in mice. The results are compared with those obtained in rats and are discussed in terms of the interactions between CRF and stress.
我们之前已经证明，应激处理和促肾上腺皮质激素释放因子（CRF）均可提高小鼠的运动活性，主要表现为在旷场中央区域活动增加。在本研究中，除了证实这些发现外，我们还进一步研究了海马齿状回、杏仁核和尾状核在介导CRF的运动刺激作用中的作用。结果表明，在所研究的脑区中，海马是CRF发挥作用的最重要神经基础。杏仁核也部分参与了CRF所产生的行为效应。然而，尾状核虽然在总体运动活动的表达中很重要，但不参与CRF对小鼠运动的影响。我们将这些结果与在大鼠中获得的结果进行了比较，并根据CRF与应激之间的相互作用进行了讨论。
