Lee E H, Tang Y P, Chai C Y
Institute of Biomedical Sciences, Academia Sinica, Taiwan, The Republic of China.
Psychopharmacology (Berl). 1987;93(3):320-3. doi: 10.1007/BF00187250.
The effects of corticotropin-releasing factor (CRF) and previously published effect of stress on the locomotor activity of mice in different regions of an open field were compared. Intracerebroventricular (ICV) administration of 0.2 microgram CRF, like stress, significantly increased center region activity; this effect was reversed by the benzodiazepine diazepam (DZP) at a dose of DZP having no significant effect alone. A dose of DZP that antagonized CRF-potentiated center region activity did not block amphetamine-stimulated center area activity. These results suggest that CRF may normally be responsible for many behavioral changes during conditions of stress.
比较了促肾上腺皮质激素释放因子（CRF）的作用以及先前发表的应激对小鼠在旷场不同区域运动活动的影响。脑室内（ICV）注射0.2微克CRF，与应激一样，显著增加了中央区域的活动；苯二氮䓬类地西泮（DZP）在单独使用无显著作用的剂量下可逆转此效应。拮抗CRF增强的中央区域活动的DZP剂量并未阻断苯丙胺刺激的中央区域活动。这些结果表明，CRF可能通常是应激状态下许多行为变化的原因。
