Kim Minlee, Slack Frank J
Department of Molecular, Cellular and Developmental Biology, Yale University, PO Box 208103, New Haven, CT, 06511, USA.
Department of Pathology, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA, 02215, USA.
J Hematol Oncol. 2014 Nov 30;7:84. doi: 10.1186/s13045-014-0084-2.
While microRNAs (miRNAs) and the KRAS oncogene are known to be dysregulated in various cancers, little is known about the role of miRNAs in the regulation of KRAS in cancer. Here we review a selection of studies published in 2014 that have contributed to our understanding of the molecular mechanisms of KRAS regulation by miRNAs and the clinical relevance of sequence variants that may interfere with functional miRNA-mediated KRAS regulation.
虽然已知微小RNA（miRNA）和KRAS癌基因在多种癌症中表达失调，但关于miRNA在癌症中对KRAS调控作用的了解却很少。在此，我们回顾了2014年发表的一系列研究，这些研究有助于我们理解miRNA对KRAS调控的分子机制，以及可能干扰功能性miRNA介导的KRAS调控的序列变异的临床相关性。
