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2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) kills glucocorticoid-sensitive thymocytes in vivo.

作者信息

McConkey D J, Orrenius S

机构信息

Department of Toxicology, Karolinska Institutet, Stockholm, Sweden.

出版信息

Biochem Biophys Res Commun. 1989 May 15;160(3):1003-8. doi: 10.1016/s0006-291x(89)80101-9.

DOI:10.1016/s0006-291x(89)80101-9
PMID:2543382
Abstract

The effect of in vivo exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on glucocorticoid- and calcium ionophore-induced DNA fragmentation in rat thymocytes was investigated. TCDD dose-dependently abolished DNA fragmentation in response to both agents after 7 days of exposure. Analysis of the time dependence of the effect revealed that after 1 or 2 days TCDD potentiated DNA fragmentation in untreated and glucocorticoid-treated thymocyte suspensions relative to controls. The DNA fragmentation in untreated thymocyte suspensions from TCDD-treated rats was completely prevented by inhibitors that block glucocorticoid-induced thymocyte suicide. Our results suggest that TCDD-induced thymic atrophy is due to Ca2+-dependent endonuclease activation.

摘要

相似文献

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2
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