内分泌系统在2,3,7,8-四氯二苯并对二恶英（TCDD）对胸腺作用中的角色。

Role of the endocrine system in the action of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the thymus.

作者信息

van Logten M J, Gupta B N, McConnell E E, Moore J A

出版信息

Toxicology. 1980;15(2):135-44. doi: 10.1016/0300-483x(80)90007-4.

Abstract

Several experiments were conducted to study the involvement of the adrenal and the pituitary gland in the acute toxic effects of TCDD. Adrenalectomized or hypophysectomized rats were treated with a single oral dose of 10 or 20 microgram of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)/kg body weight. The reduced growth rate, the hepatotoxic effects and thymic involution induced by TCDD were not prevented by the adrenalectomy. The pituitary gland did not appear to be involved in causing thymic involution. In fact, the thymic effects of TCDD intoxication were even somewhat increased in hypophysectomized rats. Treatment with growth hormone failed to prevent thymic involution or the influence of TCDD on the liver.

摘要

进行了多项实验以研究肾上腺和垂体在2,3,7,8-四氯二苯并对二恶英（TCDD）急性毒性作用中的参与情况。对肾上腺切除或垂体切除的大鼠单次经口给予10或20微克2,3,7,8-四氯二苯并对二恶英（TCDD）/千克体重。肾上腺切除并不能预防TCDD诱导的生长速率降低、肝毒性作用和胸腺退化。垂体似乎未参与引起胸腺退化。事实上，垂体切除的大鼠中，TCDD中毒对胸腺的影响甚至有所增加。生长激素治疗未能预防胸腺退化或TCDD对肝脏的影响。