Jia Meng-Qi, Jia Jun, Wang Li, Zou Hai-Xiao
State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan 430079, Hubei Province, China.
Department of Pathology, School and Hospital of Stomatology, Wuhan University, Wuhan 430079, Hubei Province, China.
World J Clin Cases. 2019 Feb 6;7(3):357-365. doi: 10.12998/wjcc.v7.i3.357.
Ghost cell odontogenic carcinoma (GCOC) is a rare malignant odontogenic epithelial tumor with features of benign calcifying odontogenic cysts. Herein, we report two new cases of GCOC and systematically review the previous literature.
In case 1, a 46-year-old man complained of painless swelling of the right maxilla for 3 years, with a 1-mo history of hemorrhinia in the right nasal cavity. In case 2, a 72-year-old man was referred to our hospital with a chief complaint of painful swelling of the right mandible. Initially, the preliminary diagnoses were ameloblastomas. Thus, the two patients underwent resection of the tumor under general anesthesia. Finally, immunohistochemical examination confirmed the diagnosis of GCOC. The patient in case 1 was followed for 2 years, with no evidence of recurrence. However, the patient in case 2 was lost to follow-up.
GCOC is a rare malignant odontogenic epithelial tumor with high recurrence. Local extensive resection is necessary for the definitive treatment of GCOC.
幽灵细胞牙源性癌（GCOC）是一种罕见的恶性牙源性上皮肿瘤，具有良性钙化牙源性囊肿的特征。在此，我们报告两例新的GCOC病例，并对既往文献进行系统综述。
病例1，一名46岁男性，主诉右侧上颌无痛性肿胀3年，右侧鼻腔出血1个月。病例2，一名72岁男性，因右侧下颌疼痛性肿胀为主诉转诊至我院。最初，初步诊断为成釉细胞瘤。因此，两名患者均在全身麻醉下接受了肿瘤切除。最后，免疫组化检查确诊为GCOC。病例1的患者随访2年，无复发迹象。然而，病例2的患者失访。
GCOC是一种罕见的恶性牙源性上皮肿瘤，复发率高。局部广泛切除是GCOC确定性治疗所必需的。
