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Pulmonary disease after treatment for Wilms tumor: a report from the national wilms tumor long-term follow-up study.治疗威尔姆斯瘤后的肺部疾病:来自全国威尔姆斯瘤长期随访研究的报告。
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Contemporary perspectives on pediatric diffuse lung disease.小儿弥漫性肺疾病的当代观点
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Diffuse cystic lung disease at high-resolution CT.高分辨率 CT 上的弥漫性囊性肺疾病。
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Late toxicity in Wilms tumor patients treated with radiotherapy at 15 years of median follow-up.中位随访15年的接受放疗的肾母细胞瘤患者的晚期毒性反应
J Pediatr Hematol Oncol. 2010 Oct;32(7):e264-7. doi: 10.1097/MPH.0b013e3181e7931a.
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Fatal pneumonitis in children with metastatic rhabdomyosarcoma following whole lung radiotherapy and sequential epirubicin.
Pediatr Blood Cancer. 2007 May;48(5):586-90. doi: 10.1002/pbc.20660.
6
Pulmonary function abnormalities in children treated with whole lung irradiation.
Pediatr Blood Cancer. 2006 Feb;46(2):222-7. doi: 10.1002/pbc.20457.
7
Pulmonary complications of radiation therapy.
Clin Chest Med. 2004 Mar;25(1):167-77. doi: 10.1016/S0272-5231(03)00126-6.
8
Lung toxicity associated with cyclophosphamide use. Two distinct patterns.与环磷酰胺使用相关的肺部毒性。两种不同模式。
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一名患有放射性肺损伤儿童的囊性肺病出现异常进展及随后的改善情况。

Unusual progression and subsequent improvement in cystic lung disease in a child with radiation-induced lung injury.

作者信息

Wolf Michael S, Chadha Ashley D, Carroll Clinton M, Borinstein Scott C, Young Lisa R

机构信息

Department of Pediatrics, Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville, TN, USA.

出版信息

Pediatr Radiol. 2015 Jul;45(7):1086-90. doi: 10.1007/s00247-014-3223-6. Epub 2014 Dec 2.

DOI:10.1007/s00247-014-3223-6
PMID:25434733
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4452450/
Abstract

Radiation-induced lung disease is a known complication of therapeutic lung irradiation, but the features have not been well described in children. We report the clinical, radiologic and histologic features of interstitial lung disease (ILD) in a 4-year-old child who had previously received lung irradiation as part of successful treatment for metastatic Wilms tumor. Her radiologic abnormalities and clinical symptoms developed in an indolent manner. Clinical improvement gradually occurred with corticosteroid therapy. However, the observed radiologic progression from interstitial and reticulonodular opacities to diffuse cystic lung disease, with subsequent improvement, is striking and has not been previously described in children.

摘要

放射性肺病是治疗性肺部放疗已知的并发症,但在儿童中的特征尚未得到充分描述。我们报告了一名4岁儿童间质性肺病(ILD)的临床、放射学和组织学特征,该儿童此前接受过肺部放疗,这是转移性肾母细胞瘤成功治疗的一部分。她的放射学异常和临床症状呈惰性发展。皮质类固醇治疗后临床症状逐渐改善。然而,观察到的放射学进展,即从间质性和网状结节状混浊发展为弥漫性囊性肺病,随后又有所改善,这一情况很显著,且此前在儿童中未曾有过描述。