Wolf Michael S, Chadha Ashley D, Carroll Clinton M, Borinstein Scott C, Young Lisa R
Department of Pediatrics, Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville, TN, USA.
Pediatr Radiol. 2015 Jul;45(7):1086-90. doi: 10.1007/s00247-014-3223-6. Epub 2014 Dec 2.
Radiation-induced lung disease is a known complication of therapeutic lung irradiation, but the features have not been well described in children. We report the clinical, radiologic and histologic features of interstitial lung disease (ILD) in a 4-year-old child who had previously received lung irradiation as part of successful treatment for metastatic Wilms tumor. Her radiologic abnormalities and clinical symptoms developed in an indolent manner. Clinical improvement gradually occurred with corticosteroid therapy. However, the observed radiologic progression from interstitial and reticulonodular opacities to diffuse cystic lung disease, with subsequent improvement, is striking and has not been previously described in children.
放射性肺病是治疗性肺部放疗已知的并发症,但在儿童中的特征尚未得到充分描述。我们报告了一名4岁儿童间质性肺病(ILD)的临床、放射学和组织学特征,该儿童此前接受过肺部放疗,这是转移性肾母细胞瘤成功治疗的一部分。她的放射学异常和临床症状呈惰性发展。皮质类固醇治疗后临床症状逐渐改善。然而,观察到的放射学进展,即从间质性和网状结节状混浊发展为弥漫性囊性肺病,随后又有所改善,这一情况很显著,且此前在儿童中未曾有过描述。