Morin L G, Austin G E, Rodey G E, Johnson J E
Department of Pathology, Emory University School of Medicine, Decatur, GA.
Clin Chem. 1989 Jun;35(6):1039-42.
Diabetic patients have an increased proportion of their immunoglobulins nonenzymically glycated. To investigate the possibility that this may contribute to increased susceptibility to infection, we compared the immunoreactivity of glycated and nonglycated human immunoglobulins against rubella and hepatitis; streptococcal exoenzyme and infectious mononucleosis; human lymphocytotoxic antigens (HLA); and Varicella zoster in terms of antigen-antibody binding, cell agglutination, cytotoxicity, and complement-fixation properties, respectively. We found no evidence to support the supposition that glycated immunoglobulins are functionally impaired.
糖尿病患者的免疫球蛋白非酶糖基化比例增加。为了研究这是否可能导致感染易感性增加，我们分别从抗原 - 抗体结合、细胞凝集、细胞毒性和补体固定特性方面，比较了糖基化和非糖基化人免疫球蛋白对风疹和肝炎、链球菌外毒素和传染性单核细胞增多症、人类淋巴细胞毒性抗原（HLA）以及水痘带状疱疹的免疫反应性。我们没有发现证据支持糖基化免疫球蛋白功能受损的假设。
