Tedeschi G, Allocca S, Di Costanzo A, Tranchino G, Quattrone A, Sasso E, Casucci G, Motta G, Ambrosio G, Bonavita V
Institute of Neurological Sciences, First Faculty of Medicine, University of Naples, Italy.
Clin Neurol Neurosurg. 1989;91(2):123-8. doi: 10.1016/s0303-8467(89)80032-0.
A number of tests have been used to identify paraclinical evidences of central nervous system (CNS) lesions in multiple sclerosis (MS). The present study was aimed to test and compare the diagnostic value of saccadic eye movements (SEM) analysis, and visual and auditory brain stem evoked responses (VER, ABER) in MS, and to study the correlation between electrophysiologic findings and clinical data. The reference group for epidemiological and statistical analysis was selected from the group of 109 suspected MS patients included in the study. SEM analysis resulted at least as sensitive as VER and ABER. SEM analysis showed good sensitivity and positive predictive value. Saccade latency resulted the most sensitive SEM parameter. Subclinical internuclear ophthalmoparesis resulted highly specific. We suggest that SEM analysis could be included into the electrophysiologic tests for identifying paraclinical evidences of CNS lesions in MS. Correlations between electrophysiologic findings and clinical data are discussed.
多项测试已被用于识别多发性硬化症（MS）中枢神经系统（CNS）病变的临床旁证。本研究旨在测试和比较眼球扫视运动（SEM）分析、视觉和听觉脑干诱发电位（VER、ABER）在MS中的诊断价值，并研究电生理结果与临床数据之间的相关性。流行病学和统计分析的参考组选自该研究纳入的109例疑似MS患者。SEM分析的敏感性至少与VER和ABER相同。SEM分析显示出良好的敏感性和阳性预测值。扫视潜伏期是最敏感的SEM参数。亚临床核间性眼肌麻痹具有高度特异性。我们建议SEM分析可纳入电生理测试，以识别MS中CNS病变的临床旁证。文中讨论了电生理结果与临床数据之间的相关性。
