Volat Fanny, Bouloumié Anne
Institut National de la Santé et de la Recherche Médicale (INSERM), Toulouse, France.
Horm Mol Biol Clin Investig. 2013 Sep;15(1):5-10. doi: 10.1515/hmbci-2013-0023.
The stroma-vascular fraction (SVF) of adipose tissue (AT) is a heterogeneous cell fraction composed of progenitor cells, endothelial cells, and immune cells. SVF plays a key role in AT homeostasis and growth as well as in obesity-associated pathologies. The SVF cell composition and phenotype are distinct according to AT location and adiposity. Such discrepancies influence AT function and are involved in obesity-associated disorders such as chronic inflammation. Investigations performed in recent years in rodents and humans provided evidence that the stroma-vascular cells contribute to the conversion of steroid hormones in AT and are also steroid targets. This review describes the link between steroids and SVF depending on gender, adiposity, and AT location and highlights the potential role of sex and corticosteroid hormones in adipogenesis, angiogenesis, and their contributions in AT inflammation.
脂肪组织（AT）的基质血管成分（SVF）是一种由祖细胞、内皮细胞和免疫细胞组成的异质细胞成分。SVF在AT内稳态和生长以及肥胖相关病理过程中起关键作用。根据AT的位置和肥胖程度，SVF的细胞组成和表型各不相同。这些差异会影响AT的功能，并参与肥胖相关疾病，如慢性炎症。近年来在啮齿动物和人类中进行的研究表明，基质血管细胞有助于AT中类固醇激素的转化，并且也是类固醇作用的靶点。本综述描述了类固醇与SVF之间基于性别、肥胖程度和AT位置的联系，并强调了性激素和皮质类固醇激素在脂肪生成、血管生成及其对AT炎症的作用中的潜在作用。
