Olson Ann Louise
Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, P. O. Box 26901, BMSB 964, Oklahoma City, OK 73190, USA.
Horm Mol Biol Clin Investig. 2013 Sep;15(3):115-21. doi: 10.1515/hmbci-2013-0019.
Skeletal muscle and adipose tissue play a major role in the regulation of whole-body glucose homeostasis. Much of the coordinated regulation of whole-body glucose homeostasis results from the regulation of lipid storage and release by adipose tissue and efficient switching between glucose oxidation and fatty acid oxidation in skeletal muscle. A control point for these biochemical actions center around the regulation of the insulin responsive glucose transporter, GLUT4. This review examines the regulation of GLUT4 in adipose tissue and skeletal muscle, in the context of the steroid nuclear hormone receptor signaling.
骨骼肌和脂肪组织在全身葡萄糖稳态的调节中发挥着主要作用。全身葡萄糖稳态的许多协调调节源于脂肪组织对脂质储存和释放的调节以及骨骼肌中葡萄糖氧化和脂肪酸氧化之间的有效转换。这些生化作用的一个控制点围绕胰岛素反应性葡萄糖转运蛋白GLUT4的调节。本综述在类固醇核激素受体信号传导的背景下研究了脂肪组织和骨骼肌中GLUT4的调节。
