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一种用于估计术后肺部并发症的预测规则的制定。

Development of a prediction rule for estimating postoperative pulmonary complications.

作者信息

Jeong Byeong-Ho, Shin Beomsu, Eom Jung Seop, Yoo Hongseok, Song Wonjun, Han Sangbin, Lee Kyung Jong, Jeon Kyeongman, Um Sang-Won, Koh Won-Jung, Suh Gee Young, Chung Man Pyo, Kim Hojoong, Kwon O Jung, Woo Sookyoung, Park Hye Yun

机构信息

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Gangnam-gu, Seoul, Republic of Korea.

Department of Internal Medicine, Pusan National University College of Medicine, Pusan, Republic of Korea.

出版信息

PLoS One. 2014 Dec 1;9(12):e113656. doi: 10.1371/journal.pone.0113656. eCollection 2014.

Abstract

Patient- and procedure-related factors associated with postoperative pulmonary complications (PPCs) have changed over the last decade. Therefore, we sought to identify independent risk factors of PPCs and to develop a clinically applicable scoring system. We retrospectively analyzed clinical data from 2,059 patients who received preoperative evaluations from respiratory physicians between June 2011 and October 2012. A new scoring system for estimating PPCs was developed using beta coefficients of the final multiple regression models. Of the 2,059 patients studied, 140 (6.8%) had PPCs. A multiple logistic regression model revealed seven independent risk factors (with scores in parentheses): age ≥70 years (2 points), current smoker (1 point), the presence of airflow limitation (1 point), American Society of Anesthesiologists class ≥2 (1 point), serum albumin <4 g/dL (1 point), emergency surgery (2 points), and non-laparoscopic abdominal/cardiac/aortic aneurysm repair surgery (4 points). The area under the curve was 0.79 (95% CI, 0.75-0.83) with the newly developed model. The new risk stratification including laparoscopic surgery has a good discriminative ability for estimating PPCs in our study cohort. Further research is needed to validate this new prediction rule.

摘要

在过去十年中,与术后肺部并发症(PPCs)相关的患者及手术相关因素已经发生了变化。因此,我们试图确定PPCs的独立危险因素,并开发一种临床适用的评分系统。我们回顾性分析了2011年6月至2012年10月期间接受呼吸内科医生术前评估的2059例患者的临床数据。利用最终多元回归模型的β系数开发了一种新的PPCs评估评分系统。在研究的2059例患者中,140例(6.8%)发生了PPCs。多元逻辑回归模型显示了七个独立危险因素(括号内为分数):年龄≥70岁(2分)、当前吸烟者(1分)、气流受限(1分)、美国麻醉医师协会分级≥2级(1分)、血清白蛋白<4 g/dL(1分)、急诊手术(2分)以及非腹腔镜腹部/心脏/主动脉瘤修复手术(4分)。新开发模型的曲线下面积为0.79(95%CI,0.75 - 0.83)。在我们的研究队列中,包括腹腔镜手术在内的新风险分层对估计PPCs具有良好的判别能力。需要进一步研究来验证这一新的预测规则。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c15/4249954/d9c094e710f5/pone.0113656.g001.jpg

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