Sinclair R, Cook R F, Mumford J A
Department of Infectious Diseases, Animal Health Trust, Newmarket, Suffolk, U.K.
J Gen Virol. 1989 Feb;70 ( Pt 2):455-9. doi: 10.1099/0022-1317-70-2-455.
Seven monoclonal antibodies (MAbs) were produced which recognized equid herpesvirus type 1 (EHV-1). Three MAbs neutralized the subtype 1 virus (strain Army 183) in the presence of complement, but did not neutralize the subtype 2 virus (strain MD). All three MAbs immunoprecipitated an Mr 83K glycoprotein from a detergent-solubilized virion envelope preparation of the subtype 1 virus. The target antigens of the four non-neutralizing MAbs (6F11, 2A4, 1F10 and 8D9) were identified by immunoblotting against purified EHV-1 virions and had respective apparent Mr values of greater than 205K, greater than 205K, 97K and 13K.
