马疱疹病毒1型糖蛋白13（gC）上一个抗原位点的特性分析
Characterization of an antigenic site on glycoprotein 13 (gC) of equid herpesvirus type-1.
作者信息
Sinclair R, Moult B J, Mumford J A
机构信息
Department of Infectious Diseases, Animals Health Trust, Newmarket, Suffolk, England.
出版信息
Arch Virol. 1993;129(1-4):327-36. doi: 10.1007/BF01316908.
PMID:7682404
Abstract
Six monoclonal antibodies directed against EHV-1 glycoprotein 13 were characterized. Five antibodies neutralized EHV-1 and were directed against a single antigenic site which comprised type-specific and type cross-reactive epitopes. Inhibition of monoclonal antibody binding to this site by post-infection equine sera suggests that it is a target of host antibody during natural infection with either EHV-1 or EHV-4.
摘要
对六种针对马疱疹病毒1型糖蛋白13的单克隆抗体进行了特性分析。五种抗体可中和马疱疹病毒1型，且针对一个单一抗原位点，该位点包含型特异性和型交叉反应性表位。感染后马血清对单克隆抗体与该位点结合的抑制作用表明，在马疱疹病毒1型或马疱疹病毒4型自然感染期间，该位点是宿主抗体的靶标。
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