Microbial Biofilm Laboratory, IRCCS Fondazione Santa Lucia, Rome 00179, Italy.
Clinical Microbiology Laboratory, IRCCS Fondazione Santa Lucia, Rome 00179, Italy.
Pathogens. 2014 Sep 5;3(3):743-58. doi: 10.3390/pathogens3030743.
The Gram-negative opportunistic pathogen, Klebsiella pneumoniae, is responsible for causing a spectrum of community-acquired and nosocomial infections and typically infects patients with indwelling medical devices, especially urinary catheters, on which this microorganism is able to grow as a biofilm. The increasingly frequent acquisition of antibiotic resistance by K. pneumoniae strains has given rise to a global spread of this multidrug-resistant pathogen, mostly at the hospital level. This scenario is exacerbated when it is noted that intrinsic resistance to antimicrobial agents dramatically increases when K. pneumoniae strains grow as a biofilm. This review will summarize the findings about the antibiotic resistance related to biofilm formation in K. pneumoniae.
革兰氏阴性机会致病菌肺炎克雷伯菌可引起各种社区获得性和医院获得性感染，通常感染留置医疗设备（尤其是导尿管）的患者，这种微生物能够在这些设备上形成生物膜。越来越多的肺炎克雷伯菌菌株获得抗生素耐药性，导致这种多药耐药病原体在全球范围内传播，主要在医院层面。当注意到当肺炎克雷伯菌菌株形成生物膜时，对抗生素的固有耐药性会显著增加时，这种情况会更加恶化。本综述将总结有关肺炎克雷伯菌生物膜形成相关抗生素耐药性的研究结果。
