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酵母中细胞色素c氧化酶亚基I和II的积累需要一种由核基因SCO1编码的线粒体膜相关蛋白。

Accumulation of the cytochrome c oxidase subunits I and II in yeast requires a mitochondrial membrane-associated protein, encoded by the nuclear SCO1 gene.

作者信息

Schulze M, Rödel G

机构信息

Institut für Genetik und Mikrobiologie, Universität München, Federal Republic of Germany.

出版信息

Mol Gen Genet. 1989 Mar;216(1):37-43. doi: 10.1007/BF00332228.

DOI:10.1007/BF00332228
PMID:2543907
Abstract

The yeast nuclear SCO1 gene is required for accumulation of the mitochondrially synthesized cytochrome c oxidase subunits I and II (COXI and COXII). We cloned and characterized the SCO1 gene. It codes for a 0.9 kb transcript. DNA sequence analysis predicts a 33 kDa protein. As shown by in vitro transcription and translation experiments in combination with import studies on isolated mitochondria, this protein is matured into a 30 kDa polypeptide which is tightly associated with a mitochondrial membrane. The possible function of the SCO1 gene product in the assembly of cytochrome c oxidase is discussed.

摘要

酵母核基因SCO1是线粒体合成的细胞色素c氧化酶亚基I和II（COXI和COXII）积累所必需的。我们克隆并鉴定了SCO1基因。它编码一个0.9 kb的转录本。DNA序列分析预测其编码一个33 kDa kDa的蛋白质。体外转录和翻译实验结合对分离线粒体的导入研究表明，该蛋白质成熟为一个30 kDa的多肽，紧密结合于线粒体膜。文中讨论了SCO1基因产物在细胞色素c氧化酶组装中的可能功能。

相似文献

1
Accumulation of the cytochrome c oxidase subunits I and II in yeast requires a mitochondrial membrane-associated protein, encoded by the nuclear SCO1 gene.酵母中细胞色素c氧化酶亚基I和II的积累需要一种由核基因SCO1编码的线粒体膜相关蛋白。
Mol Gen Genet. 1989 Mar;216(1):37-43. doi: 10.1007/BF00332228.
2
SCO1, a yeast nuclear gene essential for accumulation of mitochondrial cytochrome c oxidase subunit II.SCO1，一种对线粒体细胞色素c氧化酶亚基II的积累至关重要的酵母核基因。
Mol Gen Genet. 1988 Mar;211(3):492-8. doi: 10.1007/BF00425706.
3
Yeast SCO1 protein is required for a post-translational step in the accumulation of mitochondrial cytochrome c oxidase subunits I and II.酵母SCO1蛋白是线粒体细胞色素c氧化酶亚基I和II积累过程中翻译后步骤所必需的。
Curr Genet. 1990 Jul;18(1):13-5. doi: 10.1007/BF00321109.
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Immunological identification of yeast SCO1 protein as a component of the inner mitochondrial membrane.酵母SCO1蛋白作为线粒体内膜成分的免疫学鉴定。
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5
The Neurospora crassa cya-5 nuclear gene encodes a protein with a region of homology to the Saccharomyces cerevisiae PET309 protein and is required in a post-transcriptional step for the expression of the mitochondrially encoded COXI protein.粗糙脉孢菌的cya-5核基因编码一种与酿酒酵母PET309蛋白具有同源区域的蛋白质，并且在线粒体编码的COXI蛋白表达的转录后步骤中是必需的。
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SCO1 and SCO2 act as high copy suppressors of a mitochondrial copper recruitment defect in Saccharomyces cerevisiae.SCO1和SCO2作为酿酒酵母中线粒体铜募集缺陷的高拷贝抑制因子。
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OXA1, a Saccharomyces cerevisiae nuclear gene whose sequence is conserved from prokaryotes to eukaryotes controls cytochrome oxidase biogenesis.OXA1是一种酿酒酵母核基因，其序列从原核生物到真核生物都保守，它控制细胞色素氧化酶的生物合成。
J Mol Biol. 1994 Jun 3;239(2):201-12. doi: 10.1006/jmbi.1994.1363.

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Copper metabolism in Saccharomyces cerevisiae: an update.铜代谢在酿酒酵母中的研究进展。

本文引用的文献

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Fine structure of OXI1, the mitochondrial gene coding for subunit II of yeast cytochrome c oxidase.酵母细胞色素 c 氧化酶亚基 II 编码基因 OXI1 的精细结构。
Curr Genet. 1979 Dec;1(1):75-83. doi: 10.1007/BF00413308.
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Yeast mitochondrial outer membrane specifically binds cytoplasmically-synthesized precursors of mitochondrial proteins.酵母线粒体的外膜能够特异性地结合细胞质中合成的线粒体蛋白前体。
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Requirements for Cu(A) and Cu-S center assembly of nitrous oxide reductase deduced from complete periplasmic enzyme maturation in the nondenitrifier Pseudomonas putida.从非反硝化菌恶臭假单胞菌周质酶完全成熟过程推断一氧化二氮还原酶铜（A）和铜硫中心组装的要求
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8
Structural and functional analyses of photosynthetic regulatory genes regA and regB from Rhodovulum sulfidophilum, Roseobacter denitrificans, and Rhodobacter capsulatus.对嗜硫红假单胞菌、脱氮红杆菌和荚膜红细菌中光合调控基因regA和regB的结构与功能分析。
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10
Human cytochrome c oxidase: structure, function, and deficiency.人类细胞色素c氧化酶：结构、功能及缺陷
J Bioenerg Biomembr. 1997 Apr;29(2):151-63. doi: 10.1023/a:1022638013825.
一种展示蛋白质亲水性特征的简单方法。
J Mol Biol. 1982 May 5;157(1):105-32. doi: 10.1016/0022-2836(82)90515-0.
4
Isolation of intracellular membranes by means of sodium carbonate treatment: application to endoplasmic reticulum.通过碳酸钠处理分离细胞内膜：应用于内质网
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Codon selection in yeast.酵母中的密码子选择
J Biol Chem. 1982 Mar 25;257(6):3026-31.
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Proteinaceous receptors for the import of mitochondrial precursor proteins.用于导入线粒体前体蛋白的蛋白质受体。
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7
The nuclear-coded subunits of yeast cytochrome c oxidase. I. Fractionation of the holoenzyme into chemically pure polypeptides and the identification of two new subunits using solvent extraction and reversed phase high performance liquid chromatography.酵母细胞色素c氧化酶的核编码亚基。I. 将全酶分离为化学纯多肽，并使用溶剂萃取和反相高效液相色谱法鉴定两个新亚基。
J Biol Chem. 1984 May 25;259(10):6564-70.
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Structure of cytochrome c oxidase.细胞色素c氧化酶的结构。
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9
Import of proteins into mitochondria. Cytochrome b2 and cytochrome c peroxidase are located in the intermembrane space of yeast mitochondria.蛋白质导入线粒体。细胞色素b2和细胞色素c过氧化物酶位于酵母线粒体的膜间隙中。
J Biol Chem. 1982 Nov 10;257(21):13028-33.
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Assembly of the mitochondrial membrane system. Structure and nucleotide sequence of the gene coding for subunit 1 of yeast cytochrme oxidase.线粒体膜系统的组装。酵母细胞色素氧化酶亚基1编码基因的结构与核苷酸序列。
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