微小RNA生物合成机制相关蛋白：Drosha、DGCR8和Dicer在多发性硬化症患者中的过表达
Overexpression of microRNA biogenesis machinery: Drosha, DGCR8 and Dicer in multiple sclerosis patients.
作者信息
Jafari Naser, Shaghaghi Hassan, Mahmoodi Davood, Shirzad Zohreh, Alibeiki Fatemeh, Bohlooli Shahab, Dogaheh Hadi Peeri
机构信息
Department of Biochemistry, School of Medicine, Ardabil University of Medical Science, Ardabil, Iran; Department of Cell & Molecular Biology, School of Biology, College of Science, University of Tehran, Tehran, Iran.
Department of Biochemistry, School of Medicine, Ardabil University of Medical Science, Ardabil, Iran.
出版信息
J Clin Neurosci. 2015 Jan;22(1):200-3. doi: 10.1016/j.jocn.2014.06.106. Epub 2014 Oct 30.
We aimed to evaluate the expression of the major components of microRNA biogenesis machinery including Drosha, Dicer and DiGeorge syndrome critical region gene 8 (DGCR8) in multiple sclerosis (MS) patients. The expression levels of these components in relapsing remitting multiple sclerosis (RRMS) patients were significantly up-regulated in comparison to healthy controls. DGCR8 was up-regulated 4.9 times in RRMS patients versus healthy controls, and Drosha was up-regulated 3.58 times. Additionally, the expression level of Dicer was 2.11 times higher in RRMS patients than the healthy controls. In conclusion, our results suggest that overexpression of Drosha, Dicer and DGCR8 may contribute to the pathogenesis of MS. Further investigation may introduce microRNA biogenesis machinery as MS markers and therapeutic targets.
我们旨在评估微小RNA生物合成机制的主要成分，包括Drosha、Dicer和22q11.2微缺失综合征关键区域基因8（DGCR8）在多发性硬化症（MS）患者中的表达情况。与健康对照相比，复发缓解型多发性硬化症（RRMS）患者中这些成分的表达水平显著上调。RRMS患者的DGCR8相对于健康对照上调了4.9倍，Drosha上调了3.58倍。此外，RRMS患者中Dicer的表达水平比健康对照高2.11倍。总之，我们的结果表明，Drosha、Dicer和DGCR8的过表达可能有助于MS的发病机制。进一步的研究可能会将微小RNA生物合成机制作为MS的标志物和治疗靶点。
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