Lu Juan, Shin Yongyun, Yen Miao-Shan, Sun Shumei S
Division of Epidemiology, Department of Family Medicine and Population Health, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA.
Department of Biostatistics, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA.
J Clin Densitom. 2016 Apr-Jun;19(2):180-91. doi: 10.1016/j.jocd.2014.08.001. Epub 2014 Oct 18.
The literature has not reached a consensus on the age when peak bone mass is achieved. This study examines growth patterns of total bone mineral content (TBMC) and total bone mineral density (TBMD), peak bone mass, effect of concurrent anthropometry measures, and physical activity on growth patterns in a sample of 312 white males and 343 females aged 8-30 yr. We analyzed data from participants enrolled in Fels Longitudinal Study. Descriptive analysis was used to ascertain characteristics of participants and growth patterns of TBMC and TBMD. Mixed effects models were applied to predict ages at attainment of peak TBMC and TBMD and assess the effects of height, weight, body mass index (BMI), and habitual physical activity on the attainment. Significant differences between sexes were observed for measures of TBMC and TBMD, and differences varied with age. For females, predicted median ages at peak TBMC and TBMD attainments are 21.96 yr (interquartile range [IQR]: 21.81-22.21) and 22.31 yr (IQR: 21.95-22.59), respectively. For males, predicted median ages are 23.34 yr (IQR: 24.34-26.19) and 26.86 yr (IQR: 25.14-27.98) respectively. For females, height, weight, and BMI, but not physical activity, had significant influences on attainment of TBMC and TBMD (p<0.01). For males, weight and BMI, but not height and physical activity, exerted significant influence on attainment of TBMC and TBMD (p<0.01), and also modified correlations between age and peak TBMC and TBMD. Our results suggest that (1) for both sexes, trajectories of TBMC and TBMD follow a curvilinear pattern between ages 8 and 30 yr; (2) predicted ages at peak TBMC and TBMD are from early to late 20s for both white males and females, with females reaching their peaks significantly earlier than males; and (3) concurrent height, weight, and BMI, but not habitual physical activity, exert significant effects on trajectories of TBMC and TBMD.
关于达到峰值骨量的年龄，文献尚未达成共识。本研究调查了312名8至30岁白人男性和343名白人女性样本中总骨矿物质含量（TBMC）和总骨矿物质密度（TBMD）的生长模式、峰值骨量、同时进行的人体测量指标的影响以及身体活动对生长模式的影响。我们分析了参加费尔斯纵向研究的参与者的数据。采用描述性分析来确定参与者的特征以及TBMC和TBMD的生长模式。应用混合效应模型来预测达到TBMC和TBMD峰值的年龄，并评估身高、体重、体重指数（BMI）和习惯性身体活动对达到峰值的影响。观察到TBMC和TBMD测量值在性别之间存在显著差异，且差异随年龄而变化。对于女性，预测的TBMC和TBMD峰值达到的中位年龄分别为21.96岁（四分位间距[IQR]：21.81 - 22.21）和22.31岁（IQR：21.95 - 22.59）。对于男性，预测的中位年龄分别为23.34岁（IQR：24.34 - 26.19）和26.86岁（IQR：25.14 - 27.98）。对于女性，身高、体重和BMI对TBMC和TBMD的达到有显著影响，但身体活动没有（p<0.01）。对于男性，体重和BMI对TBMC和TBMD的达到有显著影响，但身高和身体活动没有（p<0.01），并且还改变了年龄与TBMC和TBMD峰值之间的相关性。我们的结果表明：（1）对于两性，8至30岁之间TBMC和TBMD的轨迹呈曲线模式；（2）白人男性和女性达到TBMC和TBMD峰值的预测年龄在20岁出头到接近30岁之间，女性比男性显著更早达到峰值；（3）同时存在的身高、体重和BMI对TBMC和TBMD的轨迹有显著影响，但习惯性身体活动没有。
