de Souza Santos Marcela, Orth Kim
Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Cell Microbiol. 2015 Feb;17(2):164-73. doi: 10.1111/cmi.12399. Epub 2015 Jan 8.
Entry into host cells and intracellular persistence by invasive bacteria are tightly coupled to the ability of the bacterium to disrupt the eukaryotic cytoskeletal machinery. Herein we review the main strategies used by three intracellular pathogens to harness key modulators of the cytoskeleton. Two of these bacteria, namely Listeria monocytogenes and Salmonella enterica serovar Typhimurium, exhibit quite distinct intracellular lifestyles and therefore provide a comprehensive panel for the understanding of the intricate bacteria-cytoskeleton interplay during infections. The emerging intracellular pathogen Vibrio parahaemolyticus is depicted as a developing model for the uncovering of novel mechanisms used to hijack the cytoskeleton.
侵袭性细菌进入宿主细胞并在细胞内持续存在，这与细菌破坏真核细胞骨架机制的能力紧密相关。在此，我们综述了三种细胞内病原体利用细胞骨架关键调节因子的主要策略。其中两种细菌，即单核细胞增生李斯特菌和鼠伤寒沙门氏菌，表现出截然不同的细胞内生存方式，因此为理解感染过程中复杂的细菌 - 细胞骨架相互作用提供了一个全面的范例。新出现的细胞内病原体副溶血性弧菌被描述为揭示用于劫持细胞骨架的新机制的一个发展中的模型。
