减肥手术对发病医学指标的术后效果比较。
A comparison of postoperative effects of bariatric surgery on medical markers of morbidity.
作者信息
Bonner Gwen L, Nagy Andrew J, Jupiter Daniel C, Rodriguez Joaquin A, Symmonds Richard E, Carpenter Robert O
机构信息
Baylor Scott & White, MS-01-712, 2401 S. 31st Street, Temple, TX 76508, USA.
Fourth Year Medical Student, Texas A&M Health Science Center, Temple, TX, USA.
出版信息
Am J Surg. 2014 Dec;208(6):897-902; discussion 901-2. doi: 10.1016/j.amjsurg.2014.09.005. Epub 2014 Oct 13.
BACKGROUND
Bariatric surgery reduces the prevalence of diabetes and improves lipid profiles. Low-density lipoprotein particle (LDL-P) is a more accurate predictor of cardiovascular events than high-density lipoprotein (HDL) and LDL cholesterol. The effects of bariatric procedures on LDL-P have not been previously reported.
METHODS
Two hundred thirty patients undergoing bariatric surgery, including gastric bypass, sleeve gastrectomy, and laparoscopic adjustable gastric band placement at a single institution were included. HDL, LDL, hemoglobin A1c, and LDL-P were measured preoperatively and at 3, 6, and 12 months postoperatively. Weight was recorded at baseline and after 1 year.
RESULTS
There was a decrease in serum LDL-P levels, averaging 472.58 (P < .0001) over 1 year. HDL levels increased. Hemoglobin A1c and LDL levels declined. On average, patients lost 58% of excess weight.
CONCLUSION
LDL-P significantly decreased after bariatric surgery in relation to weight loss. It may be inferred that bariatric surgery decreases the risk of cardiovascular events.
背景
减肥手术可降低糖尿病患病率并改善血脂状况。低密度脂蛋白颗粒（LDL-P）比高密度脂蛋白（HDL）和低密度脂蛋白胆固醇更能准确预测心血管事件。此前尚未报道减肥手术对LDL-P的影响。
方法
纳入在单一机构接受减肥手术的230例患者，包括胃旁路术、袖状胃切除术和腹腔镜可调节胃束带置入术。术前及术后3个月、6个月和12个月测量HDL、LDL、糖化血红蛋白和LDL-P。记录基线时及1年后的体重。
结果
血清LDL-P水平在1年内平均下降472.58（P < .0001）。HDL水平升高。糖化血红蛋白和LDL水平下降。患者平均减重58%。
结论
减肥手术后，LDL-P随体重减轻显著降低。可以推断，减肥手术可降低心血管事件的风险。
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