Johansson S, Rydqvist B, Swerup C, Heilbronn E, Arhem P
Nobel Institute for Neurophysiology, Karolinska Institutet, Stockholm, Sweden.
Acta Physiol Scand. 1989 Apr;135(4):573-8. doi: 10.1111/j.1748-1716.1989.tb08619.x.
Oat cells (of the small cell carcinoma of the lung) have been reported to generate calcium action potentials. The calcium channels have further been suggested to play a crucial role in the relation between oat cell carcinoma and the often associated myasthenic syndrome. We have examined cultured human oat cells (U-1690) under voltage-clamp conditions, using the patch-clamp technique. We found, contrary to previous reports, that the action potential was caused by sodium and potassium currents. No calcium current was detected under these conditions, which indicates that calcium channels, if present, are very rare. The findings restrict, but do not rule out, the hypothesis that calcium plays a key role in the carcinoma/myasthenic syndrome relation.
据报道，（肺小细胞癌的）燕麦细胞可产生钙动作电位。进一步有人提出，钙通道在燕麦细胞癌与常伴发的肌无力综合征之间的关系中起关键作用。我们使用膜片钳技术，在电压钳条件下对培养的人燕麦细胞（U - 1690）进行了检测。与之前的报道相反，我们发现动作电位是由钠电流和钾电流引起的。在这些条件下未检测到钙电流，这表明即使存在钙通道，其数量也非常稀少。这些发现限制了，但并未排除钙在癌症/肌无力综合征关系中起关键作用这一假说。
