Tischler A S, Dichter M A, Biales B
J Pathol. 1977 Jul;122(3):153-6. doi: 10.1002/path.1711220306.
Cultured tumour cells from two oat cell carcinomas of the lung were demonstrated to generate all-or-nothing, short-duration action potentials similar to those previously reported in neurones, in bronchial carcinoid cells, and in a number of endocrine cells of proven or proposed neural ancestry. This observation provides new evidence to establish oat cell carcinomas and carcinoids as closely related tumours distinct from other pulmonary neoplasms, and raises the possibility of treating these tumours by manipulation of hormonal agents.
来自两个肺燕麦细胞癌的培养肿瘤细胞被证明能产生全或无的、持续时间短的动作电位，类似于先前在神经元、支气管类癌细胞以及一些已证实或推测有神经起源的内分泌细胞中所报道的动作电位。这一观察结果为将燕麦细胞癌和类癌确立为与其他肺部肿瘤不同的密切相关肿瘤提供了新证据，并提出了通过操纵激素制剂来治疗这些肿瘤的可能性。
