Cohen M R, Sulaiman A R, Garancis J C, Wortmann R L
Department of Internal Medicine, Medical College of Wisconsin, Milwaukee.
Arthritis Rheum. 1989 Jun;32(6):734-40. doi: 10.1002/anr.1780320611.
Inclusion body myositis has been described as an inflammatory myopathy with distinctive clinical and pathologic features that is refractory to treatment. Ten cases of inclusion body myositis, as defined by histopathologic findings, were reviewed to determine whether the clinical characteristics are different in patients whose disease has been defined by light and electron microscopic studies compared with those whose disease has been defined by light microscopic studies alone. The clinical characteristics of both groups of patients were similar, and 2 patients have had excellent responses to treatment. Although inclusion body myositis represents a histologic subset of polymyositis, from a clinical perspective, it must be considered a nonspecific designation. Despite a generally poor prognosis, therapeutic intervention is still warranted.
包涵体肌炎被描述为一种具有独特临床和病理特征且治疗效果不佳的炎性肌病。对10例经组织病理学检查确诊的包涵体肌炎病例进行了回顾，以确定经光镜和电镜检查确诊疾病的患者与仅经光镜检查确诊疾病的患者在临床特征上是否存在差异。两组患者的临床特征相似，有2例患者对治疗反应良好。尽管包涵体肌炎是多肌炎的一个组织学亚型，但从临床角度来看，它必须被视为一种非特异性诊断。尽管总体预后较差，但仍有必要进行治疗干预。
