Otsuka Rei, Kato Yuki, Imai Tomoko, Ando Fujiko, Shimokata Hiroshi
Section of Longitudinal Study of Aging, National Institute for Longevity Sciences (NILS-LSA), National Center for Geriatrics and Gerontology, 430 7-Choume, Morioka-cho, Obu, Aichi 474-8511, Japan.
Section of Longitudinal Study of Aging, National Institute for Longevity Sciences (NILS-LSA), National Center for Geriatrics and Gerontology, 430 7-Choume, Morioka-cho, Obu, Aichi 474-8511, Japan.
Prostaglandins Leukot Essent Fatty Acids. 2015 Mar;94:35-42. doi: 10.1016/j.plefa.2014.11.002. Epub 2014 Nov 18.
Cross-sectional studies have shown age-related increases in blood docosahexaenoic and eicosapentaenoic acid and decreases in arachidonic acid. We describe serum docosahexaenoic, eicosapentaenoic, and arachidonic acid concentrations over 13 years (1997-2012) across four study waves and serum fatty acid composition over 4 years (2006-2012) between two study waves according to age groups by sex in the same subjects. We included 443 men and 435 women aged 40-79 years at baseline. Serum arachidonic acid concentrations increased in all sex and age groups over 13 years, and eicosapentaenoic or docosahexaenoic acid concentrations increased in males and females who were younger and middle-aged at baseline. Only serum arachidonic acid composition increased over 4 years in men and women who were 40-69 years at baseline, even after adjustment for arachidonic acid intake. These findings suggest a secular increase trend in serum arachidonic acid levels over 13 years among randomly selected community-dwelling middle-aged and elderly Japanese.
横断面研究表明，血液中的二十二碳六烯酸和二十碳五烯酸会随着年龄增长而增加，而花生四烯酸则会减少。我们描述了同一研究对象在13年（1997 - 2012年）内跨越四个研究阶段的血清二十二碳六烯酸、二十碳五烯酸和花生四烯酸浓度，以及在4年（2006 - 2012年）内跨越两个研究阶段的血清脂肪酸组成，并按年龄组和性别进行了划分。我们纳入了443名男性和435名年龄在40 - 79岁之间的女性作为基线研究对象。在13年的时间里，所有性别和年龄组的血清花生四烯酸浓度均有所增加，而基线时年龄较轻和中年的男性和女性的二十碳五烯酸或二十二碳六烯酸浓度有所增加。即使在对花生四烯酸摄入量进行调整之后，在基线时年龄在40 - 69岁之间的男性和女性中，只有血清花生四烯酸组成在4年中有所增加。这些研究结果表明，在随机选取的居住在社区的日本中年和老年人群中，血清花生四烯酸水平在13年中呈现出长期上升的趋势。
