Zaĭtsev V B, Raĭkhlin N T, Sokolova I N
Biull Eksp Biol Med. 1989 May;107(5):633-7.
The ultrastructural study of man's cytoskeleton of podocytes is carried out. Populations of podocytes with two different types of structure of the cytoskeleton in dependence on age (2, 4, 6, 37 and 65 years) is revealed in kidneys. The first type of cytoskeleton of the podocyte is peculiar for children's age and is characterized by branched, high density microfilament network, expressed by system of microtubules and single myofilaments. The intermediate filaments here are either utterly absent or present so feebly they find themselves "disguised" by other strongly developed components of cytoskeleton and revealing them with the help of technique of electron microscope is impossible. In kidneys of adults, and especially of old aged persons podocytes with other type of organization of the cytoskeleton are mainly identified. The distinctive signs of the last are bundle arrangement of microfilaments, plural bundles of intermediate filaments and individual microtubules. This study permits to make a conclusion that during individual development and growing old in kidneys of high animals and man, probably, physiological changes causing morphological reconstruction of cytoskeleton which is accompanied by intensive development of intermediate filaments' system with simultaneous "involution" of microtubules and microfilaments' systems take place.
对人足细胞的细胞骨架进行了超微结构研究。在肾脏中发现了根据年龄（2岁、4岁、6岁、37岁和65岁）具有两种不同类型细胞骨架结构的足细胞群体。足细胞的第一种细胞骨架类型在儿童期较为特殊，其特征是有分支的、高密度的微丝网络，由微管系统和单个肌丝表示。这里的中间丝要么完全不存在，要么非常微弱，以至于它们被细胞骨架的其他强烈发育的成分“掩盖”，借助电子显微镜技术也无法发现它们。在成年人，尤其是老年人的肾脏中，主要识别出具有其他类型细胞骨架组织的足细胞。后者的显著特征是微丝的束状排列、多束中间丝和单个微管。这项研究可以得出结论，在高等动物和人的肾脏个体发育和衰老过程中，可能发生了导致细胞骨架形态重建的生理变化，这种变化伴随着中间丝系统的强烈发育，同时微管和微丝系统“退化”。
