• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

人和大鼠足细胞及肾小球内皮细胞的细胞骨架超微结构

Cytoskeleton ultrastructure of podocytes and glomerular endothelial cells in man and in the rat.

作者信息

Vasmant D, Maurice M, Feldmann G

出版信息

Anat Rec. 1984 Sep;210(1):17-24. doi: 10.1002/ar.1092100104.

DOI:10.1002/ar.1092100104
PMID:6541441
Abstract

The ultrastructural organization of the cytoskeleton of normal podocytes and glomerular endothelial cells was studied in man (adults and children) and in adult Sprague-Dawley rats. In podocytes of both species, cytoplasmic microtubules (MT) were observed in the cell body close to the Golgi apparatus and along the main axis of the major processes where they formed bundles. A network of intermediate filaments (IF) was observed in the cell body and in the major processes where they sometimes formed bundles parallel to MT, especially in man. Numerous clustered microfilaments (MF) were noticed in the foot processes close to the plasma membrane. In glomerular endothelial cells from both species, networks of MT and IF were observed in the cell body, whereas MF surrounded the endothelial fenestrations. The high degree of organization of the cytoskeleton suggests that it may play an important role in several functions of both cell types.

摘要

对人类(成人和儿童)以及成年斯普拉格-道利大鼠的正常足细胞和肾小球内皮细胞的细胞骨架超微结构组织进行了研究。在这两个物种的足细胞中,在靠近高尔基体的细胞体以及主要突起的主轴上观察到细胞质微管(MT),它们在这些部位形成束状。在细胞体和主要突起中观察到中间丝(IF)网络,在这些部位它们有时形成与MT平行的束状,在人类中尤其如此。在靠近质膜的足突中发现了许多成簇的微丝(MF)。在这两个物种的肾小球内皮细胞中,在细胞体中观察到MT和IF网络,而MF围绕着内皮窗孔。细胞骨架的高度组织化表明它可能在这两种细胞类型的多种功能中发挥重要作用。

相似文献

1
Cytoskeleton ultrastructure of podocytes and glomerular endothelial cells in man and in the rat.人和大鼠足细胞及肾小球内皮细胞的细胞骨架超微结构
Anat Rec. 1984 Sep;210(1):17-24. doi: 10.1002/ar.1092100104.
2
[The cytoskeleton of the endothelium and mesangium of rat kidney glomeruli].[大鼠肾小球内皮细胞和系膜细胞的细胞骨架]
Tsitologiia. 1996;38(3):305-10.
3
Ultrastructure of cytoskeletal elements of endothelial and stromal cells of rat marrow.大鼠骨髓内皮细胞和基质细胞细胞骨架成分的超微结构
Anat Rec. 1990 Jun;227(2):152-8. doi: 10.1002/ar.1092270203.
4
Ultrastructural organization of contractile and cytoskeletal proteins in glomerular podocytes of chicken, rat, and man.鸡、大鼠和人类肾小球足细胞中收缩蛋白和细胞骨架蛋白的超微结构组织
Lab Invest. 1988 Nov;59(5):673-82.
5
[Electron microscopic study of the cytoskeleton of human podocytes].[人足细胞细胞骨架的电子显微镜研究]
Biull Eksp Biol Med. 1989 May;107(5):633-7.
6
Advantages of digitonin extraction to reveal the intracellular structure of rat glomerular podocytes for high-resolution scanning electron microscopy.洋地黄皂苷提取法用于揭示大鼠肾小球足细胞的细胞内结构以进行高分辨率扫描电子显微镜观察的优势。
Microsc Res Tech. 1993 Oct 15;26(3):260-71. doi: 10.1002/jemt.1070260308.
7
Cytoskeleton of podocytes in vertebrate animals and human.脊椎动物和人类足细胞的细胞骨架。
Cell Mol Biol (Noisy-le-grand). 1992 Dec;38(8):823-33.
8
Morphological alterations of the glomerular (visceral) epithelium in response to pathological and experimental situations.肾小球(脏层)上皮细胞在病理和实验情况下的形态学改变。
J Electron Microsc Tech. 1988 Jun;9(2):115-44. doi: 10.1002/jemt.1060090203.
9
Enzymatic dissection of the glomerulus.
Lab Invest. 1985 Apr;52(4):453-61.
10
Actin filament organization of foot processes in vertebrate glomerular podocytes.脊椎动物肾小球足细胞足突的肌动蛋白丝组织
Cell Tissue Res. 2007 Sep;329(3):541-57. doi: 10.1007/s00441-007-0440-4. Epub 2007 Jun 29.

引用本文的文献

1
Cytoskeleton-associated protein 4 affects podocyte cytoskeleton dynamics in diabetic kidney disease.细胞骨架相关蛋白4影响糖尿病肾病中足细胞的细胞骨架动力学。
JCI Insight. 2025 Jun 10;10(14). doi: 10.1172/jci.insight.181298. eCollection 2025 Jul 22.
2
Tau reduction impairs nephrocyte function in Drosophila.在果蝇中,tau蛋白减少会损害肾细胞功能。
BMB Rep. 2025 Apr;58(4):169-174. doi: 10.5483/BMBRep.2024-0047.
3
Glomerular Filtration Barrier Assembly: An insight.肾小球滤过屏障组装:深入剖析
Postdoc J. 2013 Apr;1(4):33-45.
4
Everolimus Stabilizes Podocyte Microtubules via Enhancing TUBB2B and DCDC2 Expression.依维莫司通过增强TUBB2B和DCDC2的表达来稳定足细胞微管。
PLoS One. 2015 Sep 2;10(9):e0137043. doi: 10.1371/journal.pone.0137043. eCollection 2015.
5
Podocytes … What's Under Yours? (Podocytes and Foot Processes and How They Change in Nephropathy).足细胞……你的下面是什么?(足细胞和足突以及它们在肾病中的变化)。
Front Endocrinol (Lausanne). 2015 Feb 23;6:9. doi: 10.3389/fendo.2015.00009. eCollection 2015.
6
Def-6, a novel regulator of small GTPases in podocytes, acts downstream of atypical protein kinase C (aPKC) λ/ι.足细胞中一种小 GTPase 的新型调节因子 Def-6,作用于非典型蛋白激酶 C(aPKC)λ/ι 的下游。
Am J Pathol. 2013 Dec;183(6):1945-1959. doi: 10.1016/j.ajpath.2013.08.026. Epub 2013 Oct 3.
7
Signaling from the podocyte intercellular junction to the actin cytoskeleton.足细胞细胞间连接到肌动蛋白细胞骨架的信号转导。
Semin Nephrol. 2012 Jul;32(4):307-18. doi: 10.1016/j.semnephrol.2012.06.002.
8
Glomerular endothelial cell fenestrations: an integral component of the glomerular filtration barrier.肾小球内皮细胞窗孔:肾小球滤过屏障的一个重要组成部分。
Am J Physiol Renal Physiol. 2009 May;296(5):F947-56. doi: 10.1152/ajprenal.90601.2008. Epub 2009 Jan 7.
9
Ezrin--a useful factor in the prognosis of nephrotic syndrome in children: an immunohistochemical approach.埃兹蛋白——儿童肾病综合征预后的一个有用因素:一种免疫组织化学方法
J Clin Pathol. 2006 Sep;59(9):916-20. doi: 10.1136/jcp.2005.031732. Epub 2006 Mar 7.
10
Expression of intermediate filaments of podocytes within nephrotic syndrome glomerulopathies in children.儿童肾病综合征肾小球病中足细胞中间丝的表达
Histochem Cell Biol. 2004 Feb;121(2):109-13. doi: 10.1007/s00418-004-0619-7. Epub 2004 Jan 23.