心房颤动的机制：转子、离子决定因素和兴奋频率。
Mechanisms of atrial fibrillation: rotors, ionic determinants, and excitation frequency.
作者信息
Berenfeld Omer, Jalife José
机构信息
Center for Arrhythmia Research, University of Michigan, 2800 Plymouth Road, Ann Arbor, MI 48109, USA.
Center for Arrhythmia Research, University of Michigan, 2800 Plymouth Road, Ann Arbor, MI 48109, USA.
出版信息
Cardiol Clin. 2014 Nov;32(4):495-506. doi: 10.1016/j.ccl.2014.07.001. Epub 2014 Oct 23.
Abstract
Atrial fibrillation (AF) is the most common cardiac arrhythmia; however, therapy is suboptimal. We review recent data on dynamics of wave propagation during AF and its mechanistic link to the substrate. Data show that the dominant frequency (DF) increase during transition to persistent AF may be explained by rotor acceleration. We discuss how translation of experimentally derived understanding of the rotors may find its way into the clinic, focusing on studies analyzing spatial distribution of DF in the atria of patients with paroxysmal versus persistent AF, and how that knowledge might contribute to improve the outcome of AF ablation procedures.
摘要
心房颤动（AF）是最常见的心律失常；然而，治疗效果并不理想。我们回顾了关于房颤期间波传播动力学及其与基质的机制联系的最新数据。数据表明，向持续性房颤转变过程中主导频率（DF）的增加可能由转子加速来解释。我们讨论了如何将从实验得出的对转子的理解转化应用于临床，重点关注分析阵发性与持续性房颤患者心房中DF空间分布的研究，以及这些知识如何有助于改善房颤消融手术的结果。
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