Lin Wen-Ya, Muo Chih-Hsin, Ku Yi-Chia, Sung Fung-Chang, Kao Chia-Hung
Department of Pediatrics, Taichung Veterans General Hospital, Taichung, Taiwan.
Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan; College of Medicine, China Medical University, Taichung, Taiwan.
Pediatr Neurol. 2014 Dec;51(6):795-9. doi: 10.1016/j.pediatrneurol.2014.06.017. Epub 2014 Jul 4.
No study has reported a relationship between febrile seizures and asthma; thus, we examined the association between these two disorders.
We identified 991 cases of children with febrile seizures as the case cohort, and the control group was matched according to age, sex, urbanization level, and their parents' occupation at a 1:4 ratio. We applied the Cox proportional hazards regression model to estimate the hazard ratios and 95% confidence intervals for asthma among the children with febrile seizures.
After 11 years of follow-up, the asthma incidence in the febrile seizure group was approximately 5% higher than that in the control group (log-rank test, P < 0.0001). The risk of asthma in the febrile seizure group was 1.41 times higher than that in the control group (95% confidence interval, 1.21-1.65; P < 0.001). Furthermore, the risk of asthma development increased (0.96 vs 3.62) in conjunction with the frequency of febrile seizure-related medical visits (one to two visits vs more than four visits; P < 0.0001).
Febrile seizures may be associated with an increase in the risk of future asthma occurrence in children. We observed a significantly higher cumulative incidence of asthma occurrence in children with more febrile seizure-related medical visits.
尚无研究报道热性惊厥与哮喘之间的关系；因此，我们研究了这两种疾病之间的关联。
我们将991例热性惊厥患儿确定为病例队列，并根据年龄、性别、城市化水平及其父母职业按1:4的比例匹配对照组。我们应用Cox比例风险回归模型来估计热性惊厥患儿患哮喘的风险比和95%置信区间。
经过11年的随访，热性惊厥组的哮喘发病率比对照组高约5%（对数秩检验，P<0.0001）。热性惊厥组患哮喘的风险比对照组高1.41倍（95%置信区间，1.21-1.65；P<0.001）。此外，随着热性惊厥相关就诊频率的增加（一至两次就诊 vs 四次以上就诊；P<0.0001），哮喘发生风险也增加（0.96 vs 3.62）。
热性惊厥可能与儿童未来患哮喘风险的增加有关。我们观察到，热性惊厥相关就诊次数较多的儿童哮喘累积发病率显著更高。
