Deixonne B, Pignodel C, Chazelet C, Joujoux J M, Raffanel C, Baumel H
Departement des'Maladies de l'Appareil Digestif et de Cancerologie Digestive, Centre Hospitalier Regional Caremeau, Nimes, France.
Eur J Surg Oncol. 1989 Jun;15(3):265-70.
Two cases of pancreatitis associated with papillary atypical hyperplastic lesions and micro-invasive cancers are reported. They are interesting from an etiopathogenic and diagnostic point of view by again illustrating the problem of transmission between hyperplastic lesions and cancer, together with the difficulties encountered in asserting the certainty of diagnosis. In each observation the association of pancreatic lesions, of all stages of hyperplasia, and of cancer can be observed. This suggests that transmission occurs between those different lesions. In such cases diagnosis of benignity or malignancy is always difficult to assert. No clinical, biological, morphological or even cytological criterion allows one to make a ruling. For this reason excision is recommended by the authors whenever the etiology of pancreatitis remains obscure and especially in the presence of important dystrophic lesions.
报告了两例与乳头非典型增生性病变及微浸润癌相关的胰腺炎病例。从病因学和诊断角度来看，它们很有意思，因为再次说明了增生性病变与癌症之间的转变问题，以及在确定诊断的确定性方面所遇到的困难。在每例观察中，均可观察到胰腺病变、增生各阶段及癌症之间的关联。这表明这些不同病变之间会发生转变。在这类病例中，良性或恶性的诊断始终难以确定。没有任何临床、生物学、形态学甚至细胞学标准能够做出明确判断。因此，作者建议，只要胰腺炎的病因仍不明确，尤其是存在重要的营养不良性病变时，应进行切除手术。
