Department of Microbiology and Infectious Diseases, Faculty of Medicine, Toho University School of Medicine, Tokyo 143-8540, Japan.
Department of Microbiology and Infectious Diseases, Faculty of Medicine, Toho University School of Medicine, Tokyo 143-8540, Japan.
J Infect Chemother. 2015 Feb;21(2):148-51. doi: 10.1016/j.jiac.2014.08.028. Epub 2014 Oct 25.
Avibactam displays potent inhibition of extended-spectrum, AmpC, KPC and some OXA β-lactamases. We examined the combinations of avibactam with ceftazidime, ceftaroline and aztreonam by the broth microdilution method against Gram-negative bacteria harboring molecularly-characterized β-lactamase genes collected in Toho University, Japan. Bacterial isolates included: Ambler class A β-lactamase-producing Enterobacteriaceae (n = 26); class C β-lactamase-producing Enterobacteriaceae (n = 9) and class D β-lactamase-producing Acinetobacter baumannii (n = 9) and Enterobacteriaceae (n = 3). Ceftazidime-avibactam, ceftaroline-avibactam ands aztreonam-avibactam were active against the strains with an extended-spectrum β-lactamase (ESBL) or AmpC enzymes, but combination with avibactam did not reduce β-lactam MICs against A. baumannii with OXA β-lactamases including carbapenemases, such as OXA-40 and -69.
阿维巴坦对广谱、AmpC、KPC 和一些 OXA 类β-内酰胺酶具有很强的抑制作用。我们用肉汤微量稀释法，检测了日本东海大学收集的具有分子特征β-内酰胺酶基因的革兰氏阴性菌中阿维巴坦与头孢他啶、头孢洛林和氨曲南的组合。细菌分离株包括：产 Ambler 类 A 内酰胺酶的肠杆菌科（n = 26）；产 C 类β-内酰胺酶的肠杆菌科（n = 9）和产 D 类β-内酰胺酶的鲍曼不动杆菌（n = 9）和肠杆菌科（n = 3）。头孢他啶-阿维巴坦、头孢洛林-阿维巴坦和氨曲南-阿维巴坦对具有超广谱β-内酰胺酶（ESBL）或 AmpC 酶的菌株有效，但与阿维巴坦联合使用并不能降低对包括碳青霉烯酶在内的 OXA 类β-内酰胺酶的鲍曼不动杆菌的β-内酰胺 MIC 值，如 OXA-40 和 -69。
