Tojo Masayoshi, Mawatari Momoko, Hayakawa Kayoko, Nagamatsu Maki, Shimada Kayo, Mezaki Kazuhisa, Sugiki Yuko, Kuroda Emi, Takeshita Nozomi, Kutsuna Satoshi, Fujiya Yoshihiro, Miyoshi-Akiyama Tohru, Kirikae Teruo, Ohmagari Norio
Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan; Disease Control and Prevention Center, Japan; Department of Infectious Diseases, Research Institute, Japan.
Disease Control and Prevention Center, Japan.
J Infect Chemother. 2015 Mar;21(3):212-4. doi: 10.1016/j.jiac.2014.08.029. Epub 2014 Oct 23.
We report a case of multidrug-resistant (MDR) Acinetobactor baumannii isolates obtained from a traveler returned from Brunei. Whole-genome sequencing analysis revealed that the isolates harbored blaOxA-23 and armA. The minimum inhibitory concentrations of antibiotics against the strain were as follows: imipenem, 32 μg/ml; meropenem, 32 μg/ml; ciprofloxacin, 16 μg/ml; amikacin, ≧ 1024 μg/ml; arbekacin, ≧ 1024 μg/ml; aztreonam, 64 μg/ml; colistin, 4 μg/ml. A. baumannii harboring both blaOxA-23 and armA is rarely reported in Japan, and, to the best of our knowledge, this is the second report of A. baumannii harboring both resistant genes in Japan.
我们报告了一例从文莱返回的旅行者身上分离出的多重耐药鲍曼不动杆菌病例。全基因组测序分析显示,分离株携带blaOxA - 23和armA。该菌株对抗生素的最低抑菌浓度如下:亚胺培南,32μg/ml;美罗培南,32μg/ml;环丙沙星,16μg/ml;阿米卡星,≧1024μg/ml;阿贝卡星,≧1024μg/ml;氨曲南,64μg/ml;黏菌素,4μg/ml。在日本,同时携带blaOxA - 23和armA的鲍曼不动杆菌鲜有报道,据我们所知,这是日本第二例同时携带这两种耐药基因的鲍曼不动杆菌报告。