Rolim Ana Emília Holanda, Henrique-Araújo Ricardo, Ferraz Eduardo Gomes, de Araújo Alves Dultra Fátima Karoline, Fernandez Luzimar Gonzaga
Post-graduation Program in Interactive Processes of Organs and Systems, Institute of Health Sciences, Federal University of Bahia, Salvador, Bahia, Brazil.
Institute of Health Sciences-ICS, Federal University of Bahia-UFBA, Department of Biofunção, Laboratory of Biochemistry, Biotechnology and Bioproducts-LBBB, Salvador, Bahia, Brazil.
Gene. 2015 Jan 10;554(2):131-9. doi: 10.1016/j.gene.2014.10.039. Epub 2014 Oct 24.
The advances in systems biology and in the development of new technological tools in analysis, as well as in the omic sciences, among which, metabolomics, and more specifically, lipidomics, have made it possible to investigate the structural and functional complexity of lipids in biological systems. Liquid chromatography and mass spectrometry are the analytical approaches most used in lipid research. Biomedical research, with the development of specific markers for lipids, together with new software development, have both enabled the early diagnosis of several illnesses, besides the evaluation of drug activity and treatment efficacy.
系统生物学的进展、分析新技术工具的开发以及组学科学（其中包括代谢组学，更具体地说是脂质组学）的发展，使得研究生物系统中脂质的结构和功能复杂性成为可能。液相色谱和质谱是脂质研究中最常用的分析方法。生物医学研究随着脂质特异性标志物的开发以及新软件的开发，除了能够评估药物活性和治疗效果外，还实现了多种疾病的早期诊断。
