Sethi Sumit, Brietzke Elisa
Interdisciplinary Laboratory for Clinical Neuroscience (LiNC), Department of Psychiatry, Universidade Federal de São Paulo - UNIFESP, São Paulo, Brazil.
Interdisciplinary Laboratory for Clinical Neuroscience (LiNC), Department of Psychiatry, Universidade Federal de São Paulo - UNIFESP, São Paulo, Brazil.
Prostaglandins Other Lipid Mediat. 2017 Jan;128-129:8-16. doi: 10.1016/j.prostaglandins.2016.12.002. Epub 2016 Dec 27.
Lipidomics or lipid-profiling is a lipid-targeted metabolomics approach aiming at comprehensive analysis of lipids in biological systems. The extent of information in the genomic and proteomic fields is greater than that in the lipidomics field, because of the complex nature of lipids and the limitations of tools for analysis. Modern technological advances in mass spectrometry and chromatography have greatly improved the developments and applications of metabolic profiling of diverse lipids in complex biological samples. Lipidomics will not only provide insights into the specific functions of lipid species in health and disease, but will also identify potential biomarkers for establishing preventive or therapeutic programs for human diseases. In this review, emphasis is given to the current advances in lipidomics technologies and their applications in disease biomarker discovery, and its clinical application. The application of lipidomics in clinical studies may provide new insights into lipid profiling and pathophysiological mechanisms. We also discuss the lipidomics for the future perspectives and their potential problems.
脂质组学或脂质谱分析是一种针对脂质的代谢组学方法，旨在对生物系统中的脂质进行全面分析。由于脂质的复杂性质以及分析工具的局限性，基因组学和蛋白质组学领域的信息程度要高于脂质组学领域。质谱和色谱技术的现代进展极大地推动了复杂生物样品中各种脂质代谢谱分析的发展和应用。脂质组学不仅将深入了解脂质种类在健康和疾病中的特定功能，还将识别潜在的生物标志物，以建立人类疾病的预防或治疗方案。在这篇综述中，重点介绍了脂质组学技术的当前进展及其在疾病生物标志物发现中的应用以及临床应用。脂质组学在临床研究中的应用可能会为脂质谱分析和病理生理机制提供新的见解。我们还讨论了脂质组学的未来前景及其潜在问题。
