McDougle Christopher J, Landino Samantha M, Vahabzadeh Arshya, O'Rourke Julia, Zurcher Nicole R, Finger Beate C, Palumbo Michelle L, Helt Jessica, Mullett Jennifer E, Hooker Jacob M, Carlezon William A
Lurie Center for Autism, Lexington, MA, United States; Massachusetts General Hospital, Boston, MA, United States; Harvard Medical School, Boston, MA, United States.
Behavioral Genetics Laboratory, Belmont, MA, United States; McLean Hospital, Belmont, MA, United States.
Brain Res. 2015 Aug 18;1617:72-92. doi: 10.1016/j.brainres.2014.09.048. Epub 2014 Nov 13.
A role for immunological involvement in autism spectrum disorder (ASD) has long been hypothesized. This review includes four sections describing (1) evidence for a relationship between familial autoimmune disorders and ASD; (2) results from post-mortem and neuroimaging studies that investigated aspects of neuroinflammation in ASD; (3) findings from animal model work in ASD involving inflammatory processes; and (4) outcomes from trials of anti-inflammatory/immune-modulating drugs in ASD that have appeared in the literature. Following each section, ideas are provided for future research, suggesting paths forward in the continuing effort to define the role of immune factors and inflammation in the pathophysiology of a subtype of ASD. This article is part of a Special Issue entitled SI: Neuroimmunology in Health And Disease.
长期以来，人们一直推测免疫参与在自闭症谱系障碍（ASD）中发挥作用。本综述包括四个部分，分别描述：（1）家族性自身免疫性疾病与ASD之间关系的证据；（2）尸检和神经影像学研究结果，这些研究调查了ASD中的神经炎症方面；（3）涉及炎症过程的ASD动物模型研究结果；（4）文献中出现的ASD抗炎/免疫调节药物试验结果。在每个部分之后，都提供了未来研究的思路，为继续努力确定免疫因素和炎症在ASD一种亚型病理生理学中的作用指明了方向。本文是名为《SI：健康与疾病中的神经免疫学》特刊的一部分。
