自闭症谱系障碍发病机制中的免疫相关因素。
Immune related factors in pathogenesis of autism spectrum disorders.
作者信息
Szachta P, Skonieczna-Żydecka K, Adler G, Karakua-Juchnowicz H, Madlani H, Ignyś I
机构信息
Vitaimmun Medical Center, Poznań, Poland.
出版信息
Eur Rev Med Pharmacol Sci. 2016 Jul;20(14):3060-72.
OBJECTIVE
Etiology of Autism Spectrum Disorders (ASD) is insufficiently known. It is suggested that genes play a crucial role in ASD but additional environmental factors to exacerbate the syndrome are needed. Recently, the inflammatory factors in ASD that may predispose to the disorder attract a great attention. Therefore, the aim of this article was to review the literature on the possible association of the immune system malfunctions with the risk of developing ASD.
MATERIALS AND METHODS
Available articles from PubMed and Google Scholar were analyzed using time descriptors: 1996-2015 and key words: autism spectrum disorder, cytokines and immune system.
RESULTS
Individuals with ASD demonstrate aberrant immune response in central nervous system, peripheral blood and gastrointestinal tract.
CONCLUSIONS
Immune malfunctions may play a role in developing ASD.
目的
自闭症谱系障碍（ASD）的病因尚不完全清楚。有研究表明基因在ASD中起关键作用，但还需要其他环境因素来加重该综合征。最近，ASD中可能诱发该疾病的炎症因子引起了广泛关注。因此，本文旨在综述关于免疫系统功能障碍与ASD发病风险之间可能关联的文献。
材料与方法
使用时间描述符（1996 - 2015年）和关键词（自闭症谱系障碍、细胞因子和免疫系统）对来自PubMed和谷歌学术的可用文章进行分析。
结果
ASD患者在中枢神经系统、外周血和胃肠道表现出异常的免疫反应。
结论
免疫功能障碍可能在ASD的发病过程中起作用。
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