Sebastião Ana M, Ribeiro Joaquim A
Instituto de Farmacologia e Neurociências, Faculdade de Medicina e Unidade de Neurociências, Instituto de Medicina Molecular, Universidade de Lisboa, Lisboa, Portugal.
Brain Res. 2015 Sep 24;1621:102-13. doi: 10.1016/j.brainres.2014.11.008. Epub 2014 Nov 13.
Synaptic plasticity mechanisms, i.e. the sequence of events that underlies persistent changes in synaptic strength as a consequence of transient alteration in neuronal firing, are greatly influenced by the 'chemical atmosphere' of the synapses, that is to say by the presence of molecules at the synaptic cleft able to fine-tune the activity of other molecules more directly related to plasticity. One of those fine tuners is adenosine, known for a long time as an ubiquitous neuromodulator and metamodulator and recognized early as influencing synaptic plasticity. In this review we will refer to the mechanisms that adenosine can use to affect plasticity, emphasizing aspects of the neurobiology of adenosine relevant to its ability to control synaptic functioning. This article is part of a Special Issue entitled Brain and Memory.
突触可塑性机制，即作为神经元放电瞬时改变结果的突触强度持续变化所依据的一系列事件，受到突触“化学环境”的极大影响，也就是说受到突触间隙中能够更直接微调与可塑性更相关的其他分子活性的分子的存在的影响。其中一个微调器是腺苷，长期以来它被认为是一种普遍存在的神经调节剂和元调节剂，并且很早就被认为会影响突触可塑性。在这篇综述中，我们将提及腺苷可用于影响可塑性的机制，重点强调与腺苷控制突触功能能力相关的神经生物学方面。本文是名为“大脑与记忆”的特刊的一部分。
