Federal University of Grande Dourados, College of Health Science, Dourados, Mato Grosso do Sul CEP 79804-970, Brazil.
J Ethnopharmacol. 2012 Aug 30;143(1):331-7. doi: 10.1016/j.jep.2012.06.044. Epub 2012 Jul 4.
Croton urucurana (Euphorbiaceae) bark is used to treat gastric ulcers. However, to our knowledge, no study has been conducted to confirm this therapeutic property.
To evaluate the antiulcerogenic effect and any possible toxic effects of Croton urucurana bark in an induced gastric ulcer model in rats.
The preventive and healing properties of Croton urucurana bark methanol extract (CUE) were evaluated in experimental models of acute (ethanol and indomethacin) and chronic (acetic acid) gastric ulcers. The gastric juice and mucous were evaluated using the pylorus ligation model, while the gastroprotective action of sulphydryl compounds and nitric oxide were analysed using the ethanol model. The toxicity was evaluated with acute and subacute toxicity tests.
No signs of toxicity were observed in the parameters analysed. All of the CUE doses tested (50, 100 and 250mg/kg) significantly reduced the gastric lesions by 70.25, 95.40 and 98.71%, respectively. Treatment with 30mg/kg lansoprazole (positive control) inhibited 82.58% of the gastric lesions. In the indomethacin model, the 50, 100 and 250mg/kg doses of CUE significantly reduced gastric damage by 67.85, 82.50 and 71.01%, respectively, and the positive control, cimetidine (200mg/kg), reduced gastric damage by 91.02%. The CUE (100mg/kg) and cimetidine (200mg/kg) treatments significantly reduced the ulcerative pathology induced by acetic acid, promoting 81.55 and 72.62% healing, respectively. Nitric oxide did not change the cytoprotection generated by CUE. However, the antiulcerogenic activity of CUE appears to involve sulphydryl compounds because CUE activity was inhibited in animals receiving a sulphydryl compound blocker. In addition, CUE exhibited systemic effects, increasing mucous production and decreasing gastric acidity.
The present study shows that Croton urucurana bark exerts gastroprotective activity in rats without causing toxicity. This effect appears to involve sulphydryl compounds, increasing mucus production and reducing gastric acidity.
巴豆属植物（大戟科）树皮用于治疗胃溃疡。然而，据我们所知，尚未有研究证实这一治疗特性。
在大鼠诱导性胃溃疡模型中评估巴豆属植物树皮甲醇提取物（CUE）的抗溃疡作用和任何可能的毒副作用。
在急性（乙醇和吲哚美辛）和慢性（乙酸）胃溃疡实验模型中评估巴豆属植物树皮甲醇提取物（CUE）的预防和愈合特性。使用幽门结扎模型评估胃液和粘液，使用乙醇模型分析巯基化合物和一氧化氮的胃保护作用。使用急性和亚急性毒性试验评估毒性。
在分析的参数中未观察到毒性迹象。所有测试剂量的 CUE（50、100 和 250mg/kg）分别显著减少了 70.25%、95.40%和 98.71%的胃损伤。30mg/kg 兰索拉唑（阳性对照）治疗抑制了 82.58%的胃损伤。在吲哚美辛模型中，CUE 的 50、100 和 250mg/kg 剂量分别显著减少了 67.85%、82.50%和 71.01%的胃损伤，阳性对照西米替丁（200mg/kg）减少了 91.02%的胃损伤。CUE（100mg/kg）和西米替丁（200mg/kg）治疗显著减少了乙酸诱导的溃疡病理，分别促进了 81.55%和 72.62%的愈合。一氧化氮没有改变 CUE 产生的细胞保护作用。然而，CUE 的抗溃疡活性似乎涉及巯基化合物，因为 CUE 活性在接受巯基化合物阻滞剂的动物中受到抑制。此外，CUE 表现出全身作用，增加粘液产生并降低胃酸度。
本研究表明，巴豆属植物树皮在大鼠中表现出胃保护活性，且无毒性。这种作用似乎涉及巯基化合物，增加粘液产生并降低胃酸度。
