Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, 41345 Gothenburg, Sweden.
Nat Rev Gastroenterol Hepatol. 2015 Jan;12(1):36-49. doi: 10.1038/nrgastro.2014.200. Epub 2014 Dec 2.
The aetiology and pathology of IBS, a functional bowel disorder thought to lack an organic cause, is largely unknown. However, studies suggest that various features, such as altered composition of the gut microbiota, together with increased intestinal permeability, a changed balance in the enteroendocrine system and a dysregulated immune system in the gut, most likely have an important role in IBS. Exactly how these entities act together and give rise to symptoms is still unknown, but an altered gut microbiota composition could lead to dysregulation of the intestinal barrier as well as the enteroendocrine and the immune systems, which (through interactions with the nervous system) might generate symptoms. This Review highlights the crosstalk between the gut microbiota, the enteroendocrine system, the immune system and the role of intestinal permeability in patients with IBS.
IBS 是一种功能性肠病，其病因和病理学尚不完全清楚，据认为该病缺乏器质性原因。然而，研究表明，各种特征，如肠道微生物群组成的改变，加上肠道通透性增加、肠内分泌系统平衡改变以及肠道免疫失调，可能在 IBS 中起重要作用。这些实体如何共同作用并导致症状仍然未知，但肠道微生物群组成的改变可能导致肠道屏障以及肠内分泌和免疫系统失调，这可能（通过与神经系统的相互作用）产生症状。这篇综述强调了肠道微生物群、肠内分泌系统、免疫系统以及肠道通透性在 IBS 患者中的作用。
