Department of Psychiatry, Postgraduate Institute of Medical Education and Research, Sector 12, Chandigarh 160012, India.
Asian J Psychiatr. 2014 Dec;12:17-22. doi: 10.1016/j.ajp.2014.09.006.
Since more than half a century, the association of urbanicity with psychosis has been explored. The research interest initially stemmed from the finding of a higher proportion of cases of psychotic disorder coming for treatment from the inner parts of cities. Subsequently, interest in the relationship of urbanicity and schizophrenia expanded and various facets of this association were explored. This narrative review provides an overview of the relationship between urbanicity and psychosis, and evaluates the link from the standpoint of causality. The review further delves into the possible risk factors and mechanisms explaining this association; both biological ones like genetic vulnerability and infections, as well as environmental ones like pollution. Since the literature has primarily emerged from the developed western countries, the review draws attention to the caveats while extrapolating the results to a developing country scenario.
半个多世纪以来，人们一直在探索城市化与精神疾病之间的关系。最初，人们对这一关系的研究兴趣源于这样一个发现，即城市中心地区接受治疗的精神障碍病例比例更高。随后，人们对城市化与精神分裂症之间关系的兴趣不断扩大，对这一关联的各个方面进行了探索。本综述概述了城市化与精神疾病之间的关系，并从因果关系的角度评估了这种联系。本综述进一步探讨了可能导致这种关联的风险因素和机制，包括遗传易感性和感染等生物学因素，以及污染等环境因素。由于文献主要来自发达国家，因此在将结果推断到发展中国家的情况时，本综述提请注意其中的局限性。
