Department of Ophthalmology, Utrecht University Medical Center, Utrecht, Netherlands.
Department of Ophthalmology, Utrecht University Medical Center, Utrecht, Netherlands.
Am J Ophthalmol. 2015 Feb;159(2):372-7.e1. doi: 10.1016/j.ajo.2014.11.007. Epub 2014 Nov 7.
To analyze inflammatory parameters as possible predictors for the development of uveitis in juvenile idiopathic arthritis (JIA) patients. Further, to analyze the predictive value of demographic and clinical factors at the onset of arthritis.
Retrospective cohort study.
In 358 children with oligoarthritis and rheumatoid factor-negative polyarthritis, erythrocyte sedimentation rate (ESR), C-reactive protein, leukocyte count, presence of antinuclear antibodies (ANA), presence of human leukocyte antigen (HLA-)B27, age of onset of JIA, and sex were analyzed for their predictive value for the onset of uveitis.
One hundred forty-seven patients (41%) were diagnosed with chronic anterior uveitis. Young age of onset, presence of ANA, and elevated ESR appeared to be predictive factors according to univariate analyses (P = .029, P = .007, and P = 5E(-4), respectively). According to multivariate analysis, young age of onset and elevated ESR appeared to be predictive after adjusting for the other relevant factors (P = .004 and P = .001, respectively). A prediction model was developed.
Elevated ESR appears to be a predictor for the occurrence of uveitis in patients with JIA. Since ESR is already routinely tested in patients with recently diagnosed arthritis, its use as a biomarker can easily be implemented in daily practice.
分析炎症参数是否可作为幼年特发性关节炎（JIA）患者发生葡萄膜炎的预测因子。此外，还分析关节炎发病时的人口统计学和临床因素的预测价值。
回顾性队列研究。
在 358 例少关节炎和类风湿因子阴性多关节炎患儿中，分析红细胞沉降率（ESR）、C 反应蛋白、白细胞计数、抗核抗体（ANA）、人类白细胞抗原（HLA）-B27 存在情况、JIA 发病年龄和性别对葡萄膜炎发病的预测价值。
147 例患者（41%）被诊断为慢性前葡萄膜炎。根据单因素分析，发病年龄较小、存在 ANA 和 ESR 升高似乎是预测因素（P =.029、P =.007 和 P = 5E（-4），分别）。根据多因素分析，在调整其他相关因素后，发病年龄较小和 ESR 升高似乎具有预测作用（P =.004 和 P =.001，分别）。建立了预测模型。
ESR 升高似乎是 JIA 患者发生葡萄膜炎的预测因子。由于 ESR 已在近期诊断为关节炎的患者中常规检测，因此其作为生物标志物的应用可在日常实践中轻松实现。
