School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore, 639798, Singapore.
Adv Mater. 2015 Jan 27;27(4):648-54. doi: 10.1002/adma.201403339. Epub 2014 Nov 29.
Antimicrobial hydrogels are prepared based on the co-assembly of commercial Fmoc-phenylalanine and Fmoc-leucine, which act as the hydrogelator and antimicrobial building block, respectively. This co-assembled antimicrobial hydrogel is demonstrated to exhibit selective bactericidal activity for gram-positive bacteria while being biocompatible with normal mammalian cells, showing great potential as an antimicrobial coating for clinical anti-infective applications.
抗菌水凝胶是基于商业 Fmoc-苯丙氨酸和 Fmoc-亮氨酸的共组装制备的，它们分别作为水凝胶剂和抗菌构建块。这种共组装的抗菌水凝胶被证明对革兰氏阳性菌具有选择性杀菌活性，同时对正常哺乳动物细胞具有生物相容性，有望成为临床抗感染应用的抗菌涂层。
