Thornley Simon, Kool Bridget, Marshall Roger J, Ameratunga Shanthi
Section of Epidemiology and Biostatistics, The University of Auckland, Tamaki Campus, 261 Morrin Road, Glen Innes, Auckland 1072, New Zealand.
N Z Med J. 2014 Nov 28;127(1406):32-8.
This study investigated whether hospitalised fall-related injuries among young and middle-aged adults were associated with short term effects of alcohol intake, marijuana use and sleep deprivation.
A case-crossover design was used to study 690 adults (aged 20 to 64 years) admitted to public hospitals within 48 hours of a fall-related injury, occurring at home, in three regions of New Zealand during August 2008 to December 2009. A matched-pair interval method of analysis was used to compare alcohol intake, marijuana use and sleep deprivation before the event with similar information in two control periods: 24 hours-before and 1 week-before the time of injury.
After adjustment for other paired exposures, the estimated risk of injury was substantially higher after consuming alcohol within the preceding 6 hours, with a dose response gradient. After adjusting for confounding variables, the data did not support a significantly elevated risk of fall-related injury associated with sleep deprivation (<6 hours sleep in the preceding 24 hours), or marijuana use in the preceding 3 hours.
The findings support the expansion of efforts to reduce the harmful effects of alcohol intake in the home environment.
本研究调查了中青年成年人住院的跌倒相关损伤是否与酒精摄入、使用大麻和睡眠剥夺的短期影响有关。
采用病例交叉设计，对2008年8月至2009年12月期间在新西兰三个地区因在家中发生跌倒相关损伤而在48小时内入住公立医院的690名成年人（年龄在20至64岁之间）进行研究。采用配对间隔分析方法，将事件发生前的酒精摄入、使用大麻和睡眠剥夺情况与两个对照期（受伤前24小时和受伤前1周）的类似信息进行比较。
在对其他配对暴露因素进行调整后，在过去6小时内饮酒后受伤的估计风险显著更高，且存在剂量反应梯度。在对混杂变量进行调整后，数据不支持与睡眠剥夺（过去24小时内睡眠<6小时）或过去3小时内使用大麻相关的跌倒相关损伤风险显著升高。
研究结果支持扩大努力以减少家庭环境中酒精摄入的有害影响。
