George Washington University, Washington, DC.
VA Eastern Colorado Health Care System, Denver, Colorado; University of Colorado School of Medicine, Denver, Colorado.
J Am Coll Cardiol. 2014 Dec 2;64(21):2196-203. doi: 10.1016/j.jacc.2014.09.022. Epub 2014 Nov 19.
Since 2003, the Seventh Report of the Joint National Committee (JNC-7) has been the predominant guideline for blood pressure management. A 2014 expert panel recommended increasing the blood pressure targets for patients age 60 years and older, as well as those with diabetes or chronic kidney disease.
The purpose of this study was to examine the effect of the 2014 expert panel blood pressure management recommendations on patients managed in U.S. ambulatory cardiovascular practices.
Using the National Cardiovascular Data Registry PINNACLE Registry, we assessed the proportion of patients who met the 2003 and 2014 panel recommendations, highlighting the populations of patients for whom the blood pressure goals changed.
Of 1,185,253 patients in the study cohort, 706,859 (59.6%) achieved the 2003 JNC-7 goals. Using the 2014 recommendations, 880,378 (74.3%) patients were at goal. Among the 173,519 (14.6%) for whom goal achievement changed, 40,323 (23.2%) had a prior stroke or transient ischemic attack, and 112,174 (64.6%) had coronary artery disease. In addition, the average Framingham risk score in this group was 8.5 ± 3.2%, and the 10-year ASCVD risk score was 28.0 ± 19.5%.
Among U.S. ambulatory cardiology patients with hypertension, nearly 1 in 7 who did not meet JNC-7 recommendations would now meet the 2014 treatment goals. If the new recommendations are implemented in clinical practice, blood pressure target achievement and cardiovascular events will need careful monitoring, because many patients for whom the target blood pressure is now more permissive are at high cardiovascular risk.
自 2003 年以来,第七次联合国家委员会报告(JNC-7)一直是血压管理的主要指南。一个 2014 年的专家小组建议提高年龄在 60 岁及以上的患者、糖尿病患者或慢性肾病患者的血压目标。
本研究旨在研究 2014 年专家小组血压管理建议对美国门诊心血管实践中患者的影响。
使用国家心血管数据注册中心 PINNACLE 注册中心,我们评估了符合 2003 年和 2014 年小组建议的患者比例,突出了血压目标改变的患者人群。
在研究队列的 1185253 名患者中,706859 名(59.6%)达到了 2003 年 JNC-7 的目标。使用 2014 年的建议,880378 名(74.3%)患者达到了目标。在 173519 名(14.6%)目标达成改变的患者中,40323 名(23.2%)有先前的中风或短暂性脑缺血发作,112174 名(64.6%)有冠心病。此外,该组的平均弗雷明汉风险评分(Framingham risk score)为 8.5±3.2%,10 年 ASCVD 风险评分(ASCVD risk score)为 28.0±19.5%。
在美国门诊心血管病高血压患者中,近 1/7 不符合 JNC-7 建议的患者现在将符合 2014 年的治疗目标。如果新建议在临床实践中得到实施,血压目标的实现和心血管事件将需要仔细监测,因为现在血压目标更宽松的许多患者处于高心血管风险之中。