Departments of Metabolic Medicine, Osaka University Graduate School of Medicine, Osaka, Japan.
Departments of Neurosurgery, Osaka University Graduate School of Medicine, Osaka, Japan.
Clin Chim Acta. 2015 Feb 2;440:93-6. doi: 10.1016/j.cca.2014.11.009. Epub 2014 Nov 15.
Glycated albumin (GA) does not reflect glycemic control in patients with disorders of albumin metabolism. In the present study, we examined GA concentrations in acromegalic patients with growth hormone (GH) excess.
We studied the hormonal status of 29 acromegalic patients (10 patients had diabetes mellitus and the remaining 19 patients were non-diabetic), 20 patients with type 2 diabetes mellitus and 38 non-diabetic subjects matched for age, sex and body mass index.
Serum GA concentrations, but not those of fasting plasma glucose, 2-h post-load plasma glucose and HbA1c, were significantly higher in non-diabetic acromegalic patients compared with non-diabetic control subjects. Serum GA concentrations, but not those of fasting plasma glucose and HbA1c, were significantly higher in diabetic acromegalic patients compared with patients with type 2 diabetes mellitus.
This is the first report describing higher GA concentrations in acromegalic patients relative to plasma glucose concentrations. Special care should be taken when evaluating glycemic control using GA because acromegaly is frequently complicated with diabetes mellitus.
糖化白蛋白（GA）不能反映白蛋白代谢紊乱患者的血糖控制情况。在本研究中，我们检查了生长激素（GH）过多的肢端肥大症患者的 GA 浓度。
我们研究了 29 例肢端肥大症患者（10 例患有糖尿病，其余 19 例非糖尿病）、20 例 2 型糖尿病患者和 38 例年龄、性别和体重指数匹配的非糖尿病对照者的激素状态。
非糖尿病肢端肥大症患者的血清 GA 浓度（而非空腹血糖、餐后 2 小时血糖和 HbA1c）明显高于非糖尿病对照组。与 2 型糖尿病患者相比，糖尿病肢端肥大症患者的血清 GA 浓度（而非空腹血糖和 HbA1c）明显升高。
这是第一个描述肢端肥大症患者 GA 浓度高于血浆葡萄糖浓度的报告。使用 GA 评估血糖控制时应特别注意，因为肢端肥大症常伴有糖尿病。
