Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Japan.
Clin Chim Acta. 2013 Sep 23;424:164-7. doi: 10.1016/j.cca.2013.06.011. Epub 2013 Jun 18.
Glycated albumin (GA) is an indicator of glycemic control, which has some specific characters in comparison with HbA1c. Since glucocorticoids (GC) promote protein catabolism including serum albumin, GC excess state would influence GA levels. We therefore investigated GA levels in patients with Cushing's syndrome.
We studied 16 patients with Cushing's syndrome (8 patients had diabetes mellitus and the remaining 8 patients were non-diabetic). Thirty-two patients with type 2 diabetes mellitus and 32 non-diabetic subjects matched for age, sex and BMI were used as controls.
In the patients with Cushing's syndrome, GA was significantly correlated with HbA1c, but the regression line shifted downwards as compared with the controls. The GA/HbA1c ratio in the patients with Cushing's syndrome was also significantly lower than the controls. HbA1c in the non-diabetic patients with Cushing's syndrome was not different from the non-diabetic controls, whereas GA was significantly lower. In 7 patients with Cushing's syndrome who performed self-monitoring of blood glucose, the measured HbA1c was matched with HbA1c estimated from mean blood glucose, whereas the measured GA was significantly lower than the estimated GA.
We clarified that GA is set lower in relation to plasma glucose levels in patients with Cushing's syndrome.
糖化白蛋白（GA）是血糖控制的一个指标，与 HbA1c 相比具有一些特定的特征。由于糖皮质激素（GC）会促进包括血清白蛋白在内的蛋白质分解代谢，GC 过多状态会影响 GA 水平。因此，我们研究了库欣综合征患者的 GA 水平。
我们研究了 16 例库欣综合征患者（8 例患有糖尿病，其余 8 例非糖尿病）。32 例 2 型糖尿病患者和 32 例年龄、性别和 BMI 相匹配的非糖尿病患者作为对照。
在库欣综合征患者中，GA 与 HbA1c 显著相关，但与对照组相比，回归线向下偏移。库欣综合征患者的 GA/HbA1c 比值也明显低于对照组。非糖尿病库欣综合征患者的 HbA1c 与非糖尿病对照组无差异，而 GA 明显降低。在 7 例进行自我监测血糖的库欣综合征患者中，测量的 HbA1c 与从平均血糖估计的 HbA1c 相匹配，而测量的 GA 明显低于估计的 GA。
我们阐明了库欣综合征患者的 GA 与血糖水平的关系较低。
