含银中心静脉导管预防导管相关血流感染的有效性：一项荟萃分析。
Effectiveness of silver-impregnated central venous catheters for preventing catheter-related blood stream infections: a meta-analysis.
作者信息
Chen Ya-Mei, Dai Ai-Ping, Shi Yan, Liu Zhan-Ju, Gong Mei-Fang, Yin Xiao-Bing
机构信息
Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University, No. 301 Middle Yanchang Road, Shanghai 200072, China.
Nursing School, Changsha Medical University, Leifeng Road, Wangcheng District, Changsha 410219, P. R. China.
出版信息
Int J Infect Dis. 2014 Dec;29:279-86. doi: 10.1016/j.ijid.2014.09.018. Epub 2014 Nov 6.
OBJECTIVES
The purpose of this meta-analysis was to examine the effectiveness of silver-impregnated central venous catheters (CVCs) in preventing catheter bacterial colonization and catheter-related blood stream infections (CRBSIs).
METHODS
PubMed, Cochrane, and Embase databases were searched up to April 30, 2014. Studies in which other antiseptic reagents were used (e.g., chlorhexidine, octenidine dihydrochloride, urokinase rinses, benzalkonium chloride, rifampin-minocycline) were excluded. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. Tests of heterogeneity and publication bias were performed.
RESULTS
Twelve studies were included in the meta-analysis. The studies enrolled a total of 2854 patients; 1440 received a standard CVC and 1414 received a silver-impregnated CVC. No significant difference in catheter bacterial colonization rates was found between silver-impregnated and standard CVCs (OR 0.907, 95% CI 0.758-1.087, p=0.290). No significant difference in CRBSI rates was found between silver-impregnated and standard CVCs (pooled OR 0.721, 95% CI 0.476-1.094, p=0.124). No significant heterogeneity or publication bias was noted.
CONCLUSIONS
Silver-impregnated CVCs are not associated with reduced rates of bacterial colonization or CRBSI.
目的
本荟萃分析旨在研究含银中心静脉导管（CVC）在预防导管细菌定植和导管相关血流感染（CRBSI）方面的有效性。
方法
检索截至2014年4月30日的PubMed、Cochrane和Embase数据库。排除使用其他抗菌试剂（如洗必泰、盐酸奥替尼啶、尿激酶冲洗液、苯扎氯铵、利福平-米诺环素）的研究。计算合并比值比（OR）和95%置信区间（CI）。进行异质性检验和发表偏倚检验。
结果
荟萃分析纳入12项研究。这些研究共纳入2854例患者；1440例接受标准CVC，1414例接受含银CVC。含银CVC与标准CVC在导管细菌定植率方面无显著差异（OR 0.907，95%CI 0.758 - 1.087，p = 0.290）。含银CVC与标准CVC在CRBSI率方面无显著差异（合并OR 0.721，95%CI 0.476 - 1.094，p = 0.124）。未发现显著的异质性或发表偏倚。
结论
含银CVC与细菌定植率或CRBSI率降低无关。
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