Kwiatkowska Angelika, Drabik Monika, Lipko Agata, Grzeczkowicz Anna, Stachowiak Radosław, Marszalik Anna, Granicka Ludomira H
Nalecz Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences, Trojdena 4 St., 02-109 Warsaw, Poland.
Institute of Microbiology, Faculty of Biology, University of Warsaw, Miecznikowa 1 St., 02-096 Warsaw, Poland.
Membranes (Basel). 2022 Feb 13;12(2):215. doi: 10.3390/membranes12020215.
Wound management is the burning problem of modern medicine, significantly burdening developed countries' healthcare systems. In recent years, it has become clear that the achievements of nanotechnology have introduced a new quality in wound healing. The application of nanomaterials in wound dressing significantly improves their properties and promotes the healing of injuries. Therefore, this review paper presents the subjectively selected nanomaterials used in wound dressings, including the metallic nanoparticles (NPs), and refers to the aspects of their application as antimicrobial factors. The literature review was supplemented with the results of our team's research on the elements of multifunctional new-generation dressings containing nanoparticles. The wound healing multiple molecular pathways, mediating cell types, and affecting agents are discussed herein. Moreover, the categorization of wound dressings is presented. Additionally, some materials and membrane constructs applied in wound dressings are described. Finally, bacterial participation in wound healing and the mechanism of the antibacterial function of nanoparticles are considered. Membranes involving NPs as the bacteriostatic factors for improving wound healing of skin and bones, including our experimental findings, are discussed in the paper. In addition, some studies of our team concerning the selected bacterial strains' interaction with material involving different metallic NPs, such as AuNPs, AgNPs, FeONPs, and CuNPs, are presented. Furthermore, nanoparticles' influence on selected eukaryotic cells is mentioned. The ideal, universal wound dressing still has not been obtained; thus, a new generation of products have been developed, represented by the nanocomposite materials with antibacterial, anti-inflammatory properties that can influence the wound-healing process.
伤口管理是现代医学的紧迫问题，给发达国家的医疗保健系统带来了沉重负担。近年来，很明显纳米技术的成果为伤口愈合带来了新的特质。纳米材料在伤口敷料中的应用显著改善了其性能，并促进了伤口愈合。因此，本文综述主观挑选了用于伤口敷料的纳米材料，包括金属纳米颗粒（NPs），并提及了它们作为抗菌因子的应用方面。文献综述补充了我们团队对含纳米颗粒的多功能新一代敷料成分的研究结果。本文讨论了伤口愈合的多种分子途径、介导细胞类型和影响因素。此外，还介绍了伤口敷料的分类。另外，描述了一些应用于伤口敷料的材料和膜结构。最后，考虑了细菌在伤口愈合中的作用以及纳米颗粒的抗菌功能机制。本文讨论了涉及纳米颗粒作为改善皮肤和骨骼伤口愈合的抑菌因子的膜，包括我们的实验结果。此外，还介绍了我们团队对所选细菌菌株与包含不同金属纳米颗粒（如金纳米颗粒、银纳米颗粒、铁氧体纳米颗粒和铜纳米颗粒）的材料相互作用的一些研究。此外，还提到了纳米颗粒对所选真核细胞的影响。理想的通用伤口敷料尚未问世；因此，已经开发出了新一代产品，以具有抗菌、抗炎特性且能影响伤口愈合过程的纳米复合材料为代表。
