Department for Neurology, Medical University Innsbruck, Austria.
Mov Disord. 2015 Feb;30(2):266-9. doi: 10.1002/mds.26060. Epub 2014 Dec 1.
In this study we report on the outcome including overall and cause-specific mortality of Parkinson's disease (PD) patients subsequent to 38 years of surveillance. This is an extension study of our previous report on mortality.
Two hundred thirty-seven patients with a symptom onset between 1974 and 1984 were followed until the date of December 31, 2012 or death, representing a follow-up period of up to 38 years. Overall and cause-specific standardized mortality ratios (SMRs) were calculated, and predictors for survival at disease onset were estimated.
Two hundred thirty patients had died by December 31, 2012; a total of 3,489 person-years were available for observation. The SMR at 38 years of follow-up was 2.02 (1.76-2.29). Employing Cox's proportional hazard modeling, male sex, gait disorder, absence of classical rest tremor, and absence of asymmetry predicted poor survival in this cohort. Increased cause-specific SMRs were found for pneumonia and cerebrovascular and cardiovascular diseases.
本研究报告了对帕金森病（PD）患者 38 年随访后全因和死因特异性死亡率的结果。这是我们之前关于死亡率研究的延伸。
237 例患者于 1974 年至 1984 年间发病，随访至 2012 年 12 月 31 日或死亡，随访时间最长达 38 年。计算了全因和死因特异性标准化死亡率比（SMR），并估计了发病时生存的预测因素。
截至 2012 年 12 月 31 日，230 例患者死亡，共观察到 3489 人年。38 年随访的 SMR 为 2.02（1.76-2.29）。采用 Cox 比例风险模型，男性、步态障碍、无经典静止性震颤和无不对称性预测了该队列的不良预后。肺炎、脑血管和心血管疾病的死因特异性 SMR 增加。
