Barnes M P, Bateman D E, Cleland P G, Dick D J, Walls T J, Newman P K, Saunders M, Tilley P J
J Neurol Neurosurg Psychiatry. 1985 Feb;48(2):157-9. doi: 10.1136/jnnp.48.2.157.
A randomised comparison is made between methylprednisolone, 1 g intravenously daily for 7 days, and a standard ACTH regime for the treatment of multiple sclerosis in acute relapse. It is found that methylprednisolone produces a more rapid clinical improvement than ACTH but confers no longer term benefit when the two treatments are compared at 3 months. It is proposed that intravenous methylprednisolone does have a role to play in the management of a patient with an acute relapse of multiple sclerosis.