复发型多发性硬化症的静脉注射甲基泼尼松龙治疗
Intravenous methylprednisolone for multiple sclerosis in relapse.
作者信息
Barnes M P, Bateman D E, Cleland P G, Dick D J, Walls T J, Newman P K, Saunders M, Tilley P J
出版信息
J Neurol Neurosurg Psychiatry. 1985 Feb;48(2):157-9. doi: 10.1136/jnnp.48.2.157.
Abstract
A randomised comparison is made between methylprednisolone, 1 g intravenously daily for 7 days, and a standard ACTH regime for the treatment of multiple sclerosis in acute relapse. It is found that methylprednisolone produces a more rapid clinical improvement than ACTH but confers no longer term benefit when the two treatments are compared at 3 months. It is proposed that intravenous methylprednisolone does have a role to play in the management of a patient with an acute relapse of multiple sclerosis.
摘要
对甲基泼尼松龙（每天静脉注射1克，共7天）和标准促肾上腺皮质激素疗法治疗急性复发型多发性硬化症进行了随机对照研究。结果发现，甲基泼尼松龙比促肾上腺皮质激素能使临床症状改善得更快，但在3个月时比较两种治疗方法，甲基泼尼松龙并无长期益处。研究表明，静脉注射甲基泼尼松龙在急性复发型多发性硬化症患者的治疗中确实有一定作用。
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