Shang Yonggang, Cui Dong, Yi Shanhong
Departmen of Urology, Xinqiao Hospital, Third Military Medical University, Chongqing, China (mainland).
Med Sci Monit. 2014 Dec 2;20:2504-7. doi: 10.12659/MSM.890902.
The blood-prostate barrier could be the major factor that preventing delivery of drugs to prostate tissue and leads to the failure of treatment. Studies indicate that ultrasonic sonoporation can break the blood-prostate barrier and increase the concentration of drugs, but the mechanism is still unclear. Tight junctions exist widely in the endothelial and epithelial cells of mammalians, and form the biological barrier, along with other factors. Through studies on the mechanism of ultrasound microbubbles opening the blood-brain barrier, researchers found that the main mechanism is to change the expression level of TJs proteins. Since there might be some similarities between the blood-brain barrier and the blood-prostate barrier, changing the expression level of TJs proteins may also be the main mechanism by which ultrasound microbubbles opens the blood-prostate barrier, which is worth further study.
血-前列腺屏障可能是阻碍药物进入前列腺组织并导致治疗失败的主要因素。研究表明，超声声孔效应可打破血-前列腺屏障并提高药物浓度，但其机制仍不清楚。紧密连接广泛存在于哺乳动物的内皮细胞和上皮细胞中，并与其他因素一起形成生物屏障。通过对超声微泡打开血脑屏障机制的研究，研究人员发现其主要机制是改变紧密连接蛋白的表达水平。由于血脑屏障和血-前列腺屏障之间可能存在一些相似之处，改变紧密连接蛋白的表达水平也可能是超声微泡打开血-前列腺屏障的主要机制，这值得进一步研究。
